Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.

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Title: Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.
Authors: Wing PAC; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Keeley TP; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK., Zhuang X; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Lee JY; Department of Biochemistry, University of Oxford, Oxford, UK., Prange-Barczynska M; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK., Tsukuda S; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Morgan SB; Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine, Experimental Medicine, University of Oxford, Oxford, UK., Harding AC; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK., Argles ILA; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kurlekar S; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Noerenberg M; Department of Biochemistry, University of Oxford, Oxford, UK; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Thompson CP; Peter Medawar Building for Pathogen Research, Department of Zoology, University of Oxford, Oxford, UK., Huang KA; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan., Balfe P; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Watashi K; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan; Department of Applied Biological Science, Tokyo University of Science, Noda 278-8510, Japan., Castello A; Department of Biochemistry, University of Oxford, Oxford, UK; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Hinks TSC; Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine, Experimental Medicine, University of Oxford, Oxford, UK., James W; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK., Ratcliffe PJ; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK; Francis Crick Institute, London, UK., Davis I; Department of Biochemistry, University of Oxford, Oxford, UK., Hodson EJ; Francis Crick Institute, London, UK; Department of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK., Bishop T; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK., McKeating JA; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK. Electronic address: jane.mckeating@ndm.ox.ac.uk.
Source: Cell reports [Cell Rep] 2021 Apr 20; Vol. 35 (3), pp. 109020. Date of Electronic Publication: 2021 Apr 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2021.109020