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Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer.

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Title: Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer.
Authors: Kazi A; Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Chen L; Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Xiang S; Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Vangipurapu R; Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Yang H; Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Beato F; Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Fang B; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Williams TM; Department of Radiation Oncology, The Ohio State University, Columbus, Ohio., Husain K; Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Underwood P; Department of Surgery, University of Florida, Gainesville, Florida., Fleming JB; Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Malafa M; Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Welsh EA; Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Koomen J; Molecular Oncology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida., Trevino J; Department of Surgery, University of Florida, Gainesville, Florida., Sebti SM; Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida. said.sebti@vcuhealth.org.; Chemical Biology and Molecular Medicine Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Jul 15; Vol. 27 (14), pp. 4012-4024. Date of Electronic Publication: 2021 Apr 20.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Kazi+A%22">Kazi A</searchLink>; Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Xiang+S%22">Xiang S</searchLink>; Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Vangipurapu+R%22">Vangipurapu R</searchLink>; Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Beato+F%22">Beato F</searchLink>; Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Fang+B%22">Fang B</searchLink>; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Williams+TM%22">Williams TM</searchLink>; Department of Radiation Oncology, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Husain+K%22">Husain K</searchLink>; Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Underwood+P%22">Underwood P</searchLink>; Department of Surgery, University of Florida, Gainesville, Florida.<br /><searchLink fieldCode="AU" term="%22Fleming+JB%22">Fleming JB</searchLink>; Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Malafa+M%22">Malafa M</searchLink>; Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Welsh+EA%22">Welsh EA</searchLink>; Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Koomen+J%22">Koomen J</searchLink>; Molecular Oncology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.<br /><searchLink fieldCode="AU" term="%22Trevino+J%22">Trevino J</searchLink>; Department of Surgery, University of Florida, Gainesville, Florida.<br /><searchLink fieldCode="AU" term="%22Sebti+SM%22">Sebti SM</searchLink>; Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida. said.sebti@vcuhealth.org.; Chemical Biology and Molecular Medicine Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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        Value: 10.1158/1078-0432.CCR-20-4781
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        Text: English
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              Text: 2021 Jul 15
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