Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.

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Title: Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.
Authors: Arveseth CD; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Happ JT; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Hedeen DS; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Zhu JF; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Capener JL; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Klatt Shaw D; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Deshpande I; Department of Pharmaceutical Chemistry, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, California, United States of America., Liang J; Department of Pharmaceutical Chemistry, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, California, United States of America., Xu J; Department of Cellular and Molecular Pharmacology, Quantitative Biosciences Institute, University of California, San Francisco, California, United States of America.; J. David Gladstone Institutes, San Francisco, California, United States of America., Stubben SL; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Nelson IB; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Walker MF; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Kawakami K; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan., Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan., Krogan NJ; Department of Cellular and Molecular Pharmacology, Quantitative Biosciences Institute, University of California, San Francisco, California, United States of America.; J. David Gladstone Institutes, San Francisco, California, United States of America., Grunwald DJ; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Hüttenhain R; Department of Cellular and Molecular Pharmacology, Quantitative Biosciences Institute, University of California, San Francisco, California, United States of America.; J. David Gladstone Institutes, San Francisco, California, United States of America., Manglik A; Department of Pharmaceutical Chemistry, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, California, United States of America., Myers BR; Department of Oncological Sciences, Department of Biochemistry, Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
Source: PLoS biology [PLoS Biol] 2021 Apr 22; Vol. 19 (4), pp. e3001191. Date of Electronic Publication: 2021 Apr 22 (Print Publication: 2021).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1545-7885
DOI:10.1371/journal.pbio.3001191