SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma.
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| Title: | SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma. |
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| Authors: | Choe JH; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Watchmaker PB; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA., Simic MS; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Gilbert RD; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA., Li AW; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Krasnow NA; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Downey KM; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA., Yu W; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Carrera DA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA., Celli A; Department of Veterans' Affairs Medical Center, University of California, San Francisco, San Francisco, CA 94158, USA., Cho J; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Briones JD; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Duecker JM; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Goretsky YE; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA., Dannenfelser R; Department of Computer Science, Princeton University, Princeton, NJ 08540, USA.; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA., Cardarelli L; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Troyanskaya O; Department of Computer Science, Princeton University, Princeton, NJ 08540, USA.; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA., Sidhu SS; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada., Roybal KT; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. kole.roybal@ucsf.edu hideho.okada@ucsf.edu wendell.lim@ucsf.edu.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA.; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.; Helen Diller Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Okada H; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94158, USA. kole.roybal@ucsf.edu hideho.okada@ucsf.edu wendell.lim@ucsf.edu.; Parker Institute for Cancer Immunotherapy, University of California, San Francisco, San Francisco, CA 94158, USA.; Helen Diller Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Lim WA; Cell Design Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. kole.roybal@ucsf.edu hideho.okada@ucsf.edu wendell.lim@ucsf.edu.; Helen Diller Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2021 Apr 28; Vol. 13 (591). |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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