Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection.

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Title: Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection.
Authors: Wheatley R; University of Oxford, Department of Zoology, Oxford, UK., Diaz Caballero J; University of Oxford, Department of Zoology, Oxford, UK., Kapel N; University of Oxford, Department of Zoology, Oxford, UK., de Winter FHR; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Wilrijk, Belgium., Jangir P; University of Oxford, Department of Zoology, Oxford, UK., Quinn A; University of Oxford, Department of Zoology, Oxford, UK., Del Barrio-Tofiño E; Hospital Universitario Son Espases, Palma de Mallorca, Spain., López-Causapé C; Hospital Universitario Son Espases, Palma de Mallorca, Spain., Hedge J; University of Oxford, Department of Zoology, Oxford, UK., Torrens G; Hospital Universitario Son Espases, Palma de Mallorca, Spain., Van der Schalk T; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Wilrijk, Belgium., Xavier BB; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Wilrijk, Belgium., Fernández-Cuenca F; Departamento de Medicina, Universidad de Sevilla, Seville, Spain., Arenzana A; Departamento de Medicina, Universidad de Sevilla, Seville, Spain., Recanatini C; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Timbermont L; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Wilrijk, Belgium., Sifakis F; Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT, USA., Ruzin A; Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Ali O; Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.; Viela Bio, Gaithersburg, MD, USA., Lammens C; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Wilrijk, Belgium., Goossens H; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Wilrijk, Belgium., Kluytmans J; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Microvida Laboratory for Medical Microbiology and Department of Infection Control, Amphia Hospital, Breda, The Netherlands., Kumar-Singh S; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Wilrijk, Belgium.; Molecular Pathology Group, Faculty of Medicine-Laboratory of Cell Biology and Histology, University of Antwerp, Wilrijk, Belgium., Oliver A; Hospital Universitario Son Espases, Palma de Mallorca, Spain., Malhotra-Kumar S; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Wilrijk, Belgium., MacLean C; University of Oxford, Department of Zoology, Oxford, UK. craig.maclean@zoo.ox.ac.uk.
Source: Nature communications [Nat Commun] 2021 Apr 28; Vol. 12 (1), pp. 2460. Date of Electronic Publication: 2021 Apr 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-021-22814-9