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Data-driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment.

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Title: Data-driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment.
Authors: Fendt R; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany.; Institute of Applied Microbiology, Aachen Biology and Biotechnology, Rheinisch-Westfaelische Technische Hochschule Aachen University, Aachen, Germany., Hofmann U; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tuebingen, Tuebingen, Germany., Schneider ARP; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany.; Institute of Applied Microbiology, Aachen Biology and Biotechnology, Rheinisch-Westfaelische Technische Hochschule Aachen University, Aachen, Germany., Schaeffeler E; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tuebingen, Tuebingen, Germany., Burghaus R; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany., Yilmaz A; Department of Cardiology I, University Hospital Muenster, Münster, Germany., Blank LM; Institute of Applied Microbiology, Aachen Biology and Biotechnology, Rheinisch-Westfaelische Technische Hochschule Aachen University, Aachen, Germany., Kerb R; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tuebingen, Tuebingen, Germany., Lippert J; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany., Schlender JF; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany., Schwab M; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; Departments of Clinical Pharmacology and Biochemistry and Pharmacy, University of Tuebingen, Tuebingen, Germany., Kuepfer L; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany.; Institute for Systems Medicine With Focus on Organ Interactions, University Hospital RWTH Aachen, Aachen, Germany.
Source: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 Jul; Vol. 10 (7), pp. 782-793. Date of Electronic Publication: 2021 Jun 26.
Publication Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Fendt+R%22">Fendt R</searchLink>; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany.; Institute of Applied Microbiology, Aachen Biology and Biotechnology, Rheinisch-Westfaelische Technische Hochschule Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Hofmann+U%22">Hofmann U</searchLink>; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+ARP%22">Schneider ARP</searchLink>; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany.; Institute of Applied Microbiology, Aachen Biology and Biotechnology, Rheinisch-Westfaelische Technische Hochschule Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Schaeffeler+E%22">Schaeffeler E</searchLink>; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Burghaus+R%22">Burghaus R</searchLink>; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany.<br /><searchLink fieldCode="AU" term="%22Yilmaz+A%22">Yilmaz A</searchLink>; Department of Cardiology I, University Hospital Muenster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Blank+LM%22">Blank LM</searchLink>; Institute of Applied Microbiology, Aachen Biology and Biotechnology, Rheinisch-Westfaelische Technische Hochschule Aachen University, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Kerb+R%22">Kerb R</searchLink>; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Lippert+J%22">Lippert J</searchLink>; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany.<br /><searchLink fieldCode="AU" term="%22Schlender+JF%22">Schlender JF</searchLink>; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany.<br /><searchLink fieldCode="AU" term="%22Schwab+M%22">Schwab M</searchLink>; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; Departments of Clinical Pharmacology and Biochemistry and Pharmacy, University of Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kuepfer+L%22">Kuepfer L</searchLink>; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany.; Institute for Systems Medicine With Focus on Organ Interactions, University Hospital RWTH Aachen, Aachen, Germany.
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