Data-driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment.

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Title: Data-driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment.
Authors: Fendt R; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany.; Institute of Applied Microbiology, Aachen Biology and Biotechnology, Rheinisch-Westfaelische Technische Hochschule Aachen University, Aachen, Germany., Hofmann U; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tuebingen, Tuebingen, Germany., Schneider ARP; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany.; Institute of Applied Microbiology, Aachen Biology and Biotechnology, Rheinisch-Westfaelische Technische Hochschule Aachen University, Aachen, Germany., Schaeffeler E; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tuebingen, Tuebingen, Germany., Burghaus R; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany., Yilmaz A; Department of Cardiology I, University Hospital Muenster, Münster, Germany., Blank LM; Institute of Applied Microbiology, Aachen Biology and Biotechnology, Rheinisch-Westfaelische Technische Hochschule Aachen University, Aachen, Germany., Kerb R; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tuebingen, Tuebingen, Germany., Lippert J; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany., Schlender JF; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany., Schwab M; Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.; Departments of Clinical Pharmacology and Biochemistry and Pharmacy, University of Tuebingen, Tuebingen, Germany., Kuepfer L; Systems Pharmacology & Medicine, Bayer AG, Leverkusen, Germany.; Institute for Systems Medicine With Focus on Organ Interactions, University Hospital RWTH Aachen, Aachen, Germany.
Source: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2021 Jul; Vol. 10 (7), pp. 782-793. Date of Electronic Publication: 2021 Jun 26.
Publication Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2163-8306
DOI:10.1002/psp4.12646