Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2'-O-methyl gapmer oligonucleotides.
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| Title: | Sequence-dependent inhibition of cGAS and TLR9 DNA sensing by 2'-O-methyl gapmer oligonucleotides. |
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| Authors: | Valentin R; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Wong C; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Alharbi AS; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia.; The Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Turabah 29179, Saudi Arabia., Pradeloux S; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Morros MP; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Lennox KA; Integrated DNA Technologies Inc., Coralville, IA 52241, USA., Ellyard JI; Department of Immunology and Infectious Diseases, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.; Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia., Garcin AJ; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Ullah TR; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Kusuma GD; Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia., Pépin G; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Li HM; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Pearson JS; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Ferrand J; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia., Lim R; Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3800, Australia.; Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia., Veedu RN; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Western Australia 6150, Australia.; Perron Institute for Neurological and Translational Science, Perth, Western Australia 6150, Australia., Morand EF; School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria 3168, Australia., Vinuesa CG; Department of Immunology and Infectious Diseases, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia.; Centre for Personalised Immunology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia., Behlke MA; Integrated DNA Technologies Inc., Coralville, IA 52241, USA., Gantier MP; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria 3800, Australia. |
| Source: | Nucleic acids research [Nucleic Acids Res] 2021 Jun 21; Vol. 49 (11), pp. 6082-6099. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1362-4962 |
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| DOI: | 10.1093/nar/gkab451 |
