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Tocilizumab is safe and tolerable and reduces C-reactive protein concentrations in the plasma and cerebrospinal fluid of ALS patients.

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Title: Tocilizumab is safe and tolerable and reduces C-reactive protein concentrations in the plasma and cerebrospinal fluid of ALS patients.
Authors: Milligan C; Department of Neurobiology and Anatomy, Wake Forest University, Winston-Salem, North Carolina, USA., Atassi N; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Boston, Massachusetts, USA., Babu S; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Boston, Massachusetts, USA., Barohn RJ; Department of Neurology, Kansas University, Kansas City, Kansas, USA., Caress JB; Department of Neurology, Wake Forest University, Winston-Salem, North Carolina, USA., Cudkowicz ME; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Boston, Massachusetts, USA., Evora A; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Boston, Massachusetts, USA., Hawkins GA; Department of Biochemistry and Center for Precision Medicine, Wake Forest University, Winston-Salem, North Carolina, USA., Wosiski-Kuhn M; Department of Neurobiology and Anatomy, Wake Forest University, Winston-Salem, North Carolina, USA., Macklin EA; Department of Medicine, Biostatistics Center, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA., Shefner JM; Department of Neurology, Gregory W. Fulton ALS and Neuromuscular Disease Center, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA., Simmons Z; Department of Neurology, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA., Bowser RP; Departments of Neurology and Neurobiology, Gregory W. Fulton ALS and Neuromuscular Disease Center, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA., Ladha SS; Department of Neurology, Gregory W. Fulton ALS and Neuromuscular Disease Center, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
Source: Muscle & nerve [Muscle Nerve] 2021 Sep; Vol. 64 (3), pp. 309-320. Date of Electronic Publication: 2021 Jun 24.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 7803146 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4598 (Electronic) Linking ISSN: 0148639X NLM ISO Abbreviation: Muscle Nerve Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tocilizumab is safe and tolerable and reduces C-reactive protein concentrations in the plasma and cerebrospinal fluid of ALS patients.
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  Data: <searchLink fieldCode="AU" term="%22Milligan+C%22">Milligan C</searchLink>; Department of Neurobiology and Anatomy, Wake Forest University, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Atassi+N%22">Atassi N</searchLink>; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Babu+S%22">Babu S</searchLink>; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Barohn+RJ%22">Barohn RJ</searchLink>; Department of Neurology, Kansas University, Kansas City, Kansas, USA.<br /><searchLink fieldCode="AU" term="%22Caress+JB%22">Caress JB</searchLink>; Department of Neurology, Wake Forest University, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Cudkowicz+ME%22">Cudkowicz ME</searchLink>; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Evora+A%22">Evora A</searchLink>; Department of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Hawkins+GA%22">Hawkins GA</searchLink>; Department of Biochemistry and Center for Precision Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Wosiski-Kuhn+M%22">Wosiski-Kuhn M</searchLink>; Department of Neurobiology and Anatomy, Wake Forest University, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Macklin+EA%22">Macklin EA</searchLink>; Department of Medicine, Biostatistics Center, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Shefner+JM%22">Shefner JM</searchLink>; Department of Neurology, Gregory W. Fulton ALS and Neuromuscular Disease Center, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.<br /><searchLink fieldCode="AU" term="%22Simmons+Z%22">Simmons Z</searchLink>; Department of Neurology, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Bowser+RP%22">Bowser RP</searchLink>; Departments of Neurology and Neurobiology, Gregory W. Fulton ALS and Neuromuscular Disease Center, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.<br /><searchLink fieldCode="AU" term="%22Ladha+SS%22">Ladha SS</searchLink>; Department of Neurology, Gregory W. Fulton ALS and Neuromuscular Disease Center, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
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  Data: <searchLink fieldCode="JN" term="%227803146%22">Muscle & nerve</searchLink> [Muscle Nerve] 2021 Sep; Vol. 64 (3), pp. 309-320. <i>Date of Electronic Publication: </i>2021 Jun 24.
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