NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
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| Title: | NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. |
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| Authors: | Flanagan DJ; Cancer Research UK Beatson Institute, Glasgow, UK., Pentinmikko N; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland., Luopajärvi K; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland., Willis NJ; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, London, UK., Gilroy K; Cancer Research UK Beatson Institute, Glasgow, UK.; SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA., Raven AP; Cancer Research UK Beatson Institute, Glasgow, UK.; SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA., Mcgarry L; Cancer Research UK Beatson Institute, Glasgow, UK., Englund JI; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland., Webb AT; Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden., Scharaw S; Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden., Nasreddin N; Intestinal Stem Cell Biology Lab, Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK., Hodder MC; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Ridgway RA; Cancer Research UK Beatson Institute, Glasgow, UK., Minnee E; Cancer Research UK Beatson Institute, Glasgow, UK.; Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Sphyris N; Cancer Research UK Beatson Institute, Glasgow, UK., Gilchrist E; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Najumudeen AK; Cancer Research UK Beatson Institute, Glasgow, UK., Romagnolo B; Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France., Perret C; Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France., Williams AC; Colorectal Tumour Biology Group, School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK., Clevers H; SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, Utrecht, The Netherlands., Nummela P; Department of Pathology, Applied Tumor Genomics, Research Programs Unit and HUSLAB, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Lähde M; Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Wihuri Research Institute, University of Helsinki, Helsinki, Finland., Alitalo K; Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Wihuri Research Institute, University of Helsinki, Helsinki, Finland., Hietakangas V; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland., Hedley A; Cancer Research UK Beatson Institute, Glasgow, UK., Clark W; Cancer Research UK Beatson Institute, Glasgow, UK., Nixon C; Cancer Research UK Beatson Institute, Glasgow, UK., Kirschner K; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Jones EY; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Ristimäki A; Department of Pathology, Applied Tumor Genomics, Research Programs Unit and HUSLAB, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Leedham SJ; Intestinal Stem Cell Biology Lab, Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK., Fish PV; Alzheimer's Research UK UCL Drug Discovery Institute, University College London, London, UK.; The Francis Crick Institute, London, UK., Vincent JP; The Francis Crick Institute, London, UK., Katajisto P; Institute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland. pekka.katajisto@helsinki.fi.; Molecular and Integrative Bioscience Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland. pekka.katajisto@helsinki.fi.; Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden. pekka.katajisto@helsinki.fi., Sansom OJ; Cancer Research UK Beatson Institute, Glasgow, UK. o.sansom@beatson.gla.ac.uk.; SpecifiCancer CRUK Grand Challenge Team (C7932/A29055), Department of Genetics, Harvard Medical School, Boston, MA, USA. o.sansom@beatson.gla.ac.uk.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. o.sansom@beatson.gla.ac.uk. |
| Source: | Nature [Nature] 2021 Jun; Vol. 594 (7863), pp. 430-435. Date of Electronic Publication: 2021 Jun 02. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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