SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung.
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| Title: | SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung. |
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| Authors: | Routhu NK; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Cheedarla N; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Bollimpelli VS; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Gangadhara S; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Edara VV; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA., Lai L; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA., Sahoo A; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Shiferaw A; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Styles TM; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Floyd K; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA., Fischinger S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Atyeo C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Shin SA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Gumber S; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA., Kirejczyk S; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA., Dinnon KH 3rd; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA., Shi PY; Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA., Menachery VD; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, USA., Tomai M; 3M Corporate Research Materials Laboratory, Saint Paul, MN, USA., Fox CB; Infectious Disease Research Institute, Seattle, WA, USA., Alter G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Vanderford TH; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA., Gralinski L; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Suthar MS; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA., Amara RR; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. ramara@emory.edu.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA. ramara@emory.edu. |
| Source: | Nature communications [Nat Commun] 2021 Jun 11; Vol. 12 (1), pp. 3587. Date of Electronic Publication: 2021 Jun 11. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-021-23942-y |
