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SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung.

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Title: SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung.
Authors: Routhu NK; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Cheedarla N; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Bollimpelli VS; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Gangadhara S; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Edara VV; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA., Lai L; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA., Sahoo A; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Shiferaw A; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Styles TM; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA., Floyd K; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA., Fischinger S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Atyeo C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Shin SA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Gumber S; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA., Kirejczyk S; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA., Dinnon KH 3rd; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA., Shi PY; Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA., Menachery VD; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, USA., Tomai M; 3M Corporate Research Materials Laboratory, Saint Paul, MN, USA., Fox CB; Infectious Disease Research Institute, Seattle, WA, USA., Alter G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Vanderford TH; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA., Gralinski L; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Suthar MS; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA., Amara RR; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. ramara@emory.edu.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA. ramara@emory.edu.
Source: Nature communications [Nat Commun] 2021 Jun 11; Vol. 12 (1), pp. 3587. Date of Electronic Publication: 2021 Jun 11.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung.
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  Data: <searchLink fieldCode="AU" term="%22Routhu+NK%22">Routhu NK</searchLink>; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Cheedarla+N%22">Cheedarla N</searchLink>; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Bollimpelli+VS%22">Bollimpelli VS</searchLink>; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Gangadhara+S%22">Gangadhara S</searchLink>; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Edara+VV%22">Edara VV</searchLink>; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Lai+L%22">Lai L</searchLink>; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Sahoo+A%22">Sahoo A</searchLink>; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Shiferaw+A%22">Shiferaw A</searchLink>; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Styles+TM%22">Styles TM</searchLink>; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Floyd+K%22">Floyd K</searchLink>; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Fischinger+S%22">Fischinger S</searchLink>; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Atyeo+C%22">Atyeo C</searchLink>; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shin+SA%22">Shin SA</searchLink>; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gumber+S%22">Gumber S</searchLink>; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kirejczyk+S%22">Kirejczyk S</searchLink>; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Dinnon+KH+3rd%22">Dinnon KH 3rd</searchLink>; Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Shi+PY%22">Shi PY</searchLink>; Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Menachery+VD%22">Menachery VD</searchLink>; Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Tomai+M%22">Tomai M</searchLink>; 3M Corporate Research Materials Laboratory, Saint Paul, MN, USA.<br /><searchLink fieldCode="AU" term="%22Fox+CB%22">Fox CB</searchLink>; Infectious Disease Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Alter+G%22">Alter G</searchLink>; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vanderford+TH%22">Vanderford TH</searchLink>; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Gralinski+L%22">Gralinski L</searchLink>; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Suthar+MS%22">Suthar MS</searchLink>; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Amara+RR%22">Amara RR</searchLink>; Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. ramara@emory.edu.; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA, USA. ramara@emory.edu.
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