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Phenyl bioisosteres in medicinal chemistry: discovery of novel γ-secretase modulators as a potential treatment for Alzheimer's disease.

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Title: Phenyl bioisosteres in medicinal chemistry: discovery of novel γ-secretase modulators as a potential treatment for Alzheimer's disease.
Authors: Ratni H; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Baumann K; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Bellotti P; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Cook XA; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Green LG; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Luebbers T; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Reutlinger M; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Stepan AF; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Vifian W; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748.
Source: RSC medicinal chemistry [RSC Med Chem] 2021 Apr 12; Vol. 12 (5), pp. 758-766. Date of Electronic Publication: 2021 Apr 12 (Print Publication: 2021).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2632-8682
DOI:10.1039/d1md00043h