Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors.

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Title: Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors.
Authors: Schneider MA; Swiss Hepato-Pancreato-Biliary (HPB) and Transplantation Center, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland.; Department of Surgery & Transplantation, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland., Linecker M; Swiss Hepato-Pancreato-Biliary (HPB) and Transplantation Center, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland.; Department of Surgery & Transplantation, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland., Fritsch R; Swiss Hepato-Pancreato-Biliary (HPB) and Transplantation Center, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland.; Department of Oncology, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland., Muehlematter UJ; Institute of Interventional and Diagnostic Radiology, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland., Stocker D; Institute of Interventional and Diagnostic Radiology, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland., Pestalozzi B; Swiss Hepato-Pancreato-Biliary (HPB) and Transplantation Center, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland.; Department of Oncology, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland., Samaras P; Oncology Center, Hirslanden Hospital Zurich, Witellikerstrasse 40, Zurich, Switzerland., Jetter A; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland., Kron P; Swiss Hepato-Pancreato-Biliary (HPB) and Transplantation Center, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland.; Department of Surgery & Transplantation, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland., Petrowsky H; Swiss Hepato-Pancreato-Biliary (HPB) and Transplantation Center, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland.; Department of Surgery & Transplantation, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland., Nicolau C; Friedman School of Nutrition Science and Policy, Tufts University, 150 Harrison Ave, Boston, MA, USA., Lehn JM; Institut de Science et d'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, 8 allée Gaspard Monge, Strasbourg, France., Humar B; Swiss Hepato-Pancreato-Biliary (HPB) and Transplantation Center, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland.; Department of Surgery & Transplantation, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland., Graf R; Swiss Hepato-Pancreato-Biliary (HPB) and Transplantation Center, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland.; Department of Surgery & Transplantation, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland., Clavien PA; Swiss Hepato-Pancreato-Biliary (HPB) and Transplantation Center, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland. clavien@access.uzh.ch.; Department of Surgery & Transplantation, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland. clavien@access.uzh.ch., Limani P; Swiss Hepato-Pancreato-Biliary (HPB) and Transplantation Center, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland. perparim.limani@usz.ch.; Department of Surgery & Transplantation, University Hospital Zurich, Raemistrasse 100, Zurich, Switzerland. perparim.limani@usz.ch.
Source: Nature communications [Nat Commun] 2021 Jun 21; Vol. 12 (1), pp. 3807. Date of Electronic Publication: 2021 Jun 21.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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