A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage.
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| Title: | A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage. |
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| Authors: | Zou X; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK., Koh GCC; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK., Nanda AS; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Degasperi A; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK., Urgo K; Wellcome Sanger Institute, Hinxton, UK., Roumeliotis TI; The Institute of Cancer Research, Chester Beatty Laboratories, London, UK., Agu CA; Wellcome Sanger Institute, Hinxton, UK., Badja C; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK., Momen S; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Young J; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Amarante TD; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Side L; UCL Institute for Women's Health, Great Ormond Street Hospital, London, UK.; Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK., Brice G; Southwest Thames Regional Genetics Service, St George's University of London, London, UK., Perez-Alonso V; Pediatrics Department, Doce de Octubre University Hospital, i+12 Research Institute, Madrid, Spain., Rueda D; Hereditary Cancer Laboratory, Doce de Octubre University Hospital, i+12 Research Institute, Madrid, Spain., Gomez C; Wellcome Sanger Institute, Hinxton, UK., Bushell W; Wellcome Sanger Institute, Hinxton, UK., Harris R; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK., Choudhary JS; The Institute of Cancer Research, Chester Beatty Laboratories, London, UK., Jiricny J; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.; Institute of Biochemistry, ETH Zurich, Zurich, Switzerland., Skarnes WC; Wellcome Sanger Institute, Hinxton, UK.; William Harvey Research Institute, Queen Mary University of London, London, UK., Nik-Zainal S; Academic Department of Medical Genetics, School of Clinical Medicine, University of Cambridge, Cambridge, UK. snz@mrc-cu.cam.ac.uk.; MRC Cancer Unit, University of Cambridge, Cambridge, UK. snz@mrc-cu.cam.ac.uk.; Wellcome Sanger Institute, Hinxton, UK. snz@mrc-cu.cam.ac.uk. |
| Corporate Authors: | Genomics England Research Consortium |
| Source: | Nature cancer [Nat Cancer] 2021 Jun; Vol. 2 (6), pp. 643-657. Date of Electronic Publication: 2021 Apr 26. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer |
| Database: | MEDLINE Ultimate |
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