Molecular design of the γδT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing.

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Title: Molecular design of the γδT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing.
Authors: Mallis RJ; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.; Department of Dermatology, Harvard Medical School, Boston, MA 02115.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115., Duke-Cohan JS; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115., Das DK; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235., Akitsu A; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115., Luoma AM; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637., Banik D; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235., Stephens HM; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235., Tetteh PW; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115., Castro CD; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637., Krahnke S; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637., Hussey RE; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115., Lawney B; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115., Brazin KN; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115., Reche PA; Department of Immunology, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain., Hwang W; Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843; hwm@tamu.edu ejadams@uchicago.edu matt.lang@vanderbilt.edu ellis_reinherz@dfci.harvard.edu.; Department of Materials Science and Engineering, Texas A&M University, College Station, TX 77843.; Department of Physics and Astronomy, Texas A&M University, College Station, TX 77843.; School of Computational Sciences, Korea Institute for Advanced Study, 02455 Seoul, Korea., Adams EJ; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637; hwm@tamu.edu ejadams@uchicago.edu matt.lang@vanderbilt.edu ellis_reinherz@dfci.harvard.edu., Lang MJ; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235; hwm@tamu.edu ejadams@uchicago.edu matt.lang@vanderbilt.edu ellis_reinherz@dfci.harvard.edu.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235., Reinherz EL; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115; hwm@tamu.edu ejadams@uchicago.edu matt.lang@vanderbilt.edu ellis_reinherz@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jun 29; Vol. 118 (26).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2023050118