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Phase I study of daily and weekly regimens of the orally administered MDM2 antagonist idasanutlin in patients with advanced tumors.

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Title: Phase I study of daily and weekly regimens of the orally administered MDM2 antagonist idasanutlin in patients with advanced tumors.
Authors: Italiano A; Institut Bergonié, Bordeaux, France.; Gustave Roussy, Villejuif, France.; Faculty of Medicine, University of Bordeaux, Bordeaux, France., Miller WH Jr; Segal Cancer Centre, Jewish General Hospital, McGill University, Montreal, QC, Canada., Blay JY; Centre Léon Bérard, Lyon, France., Gietema JA; University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Bang YJ; Seoul National University College of Medicine, Seoul, South Korea., Mileshkin LR; Peter MacCallum Cancer Center, Melbourne, Australia., Hirte HW; Juravinski Cancer Centre, Hamilton, ON, Canada., Higgins B; Roche Innovation Center, Hoffmann-La Roche, New York, NY, USA., Blotner S; Roche Innovation Center, Hoffmann-La Roche, New York, NY, USA., Nichols GL; Roche Innovation Center, Hoffmann-La Roche, New York, NY, USA., Chen LC; Roche Innovation Center, Hoffmann-La Roche, New York, NY, USA., Petry C; Roche Innovation Center, Basel, Switzerland., Yang QJ; Certara, Montréal, QC, Canada., Schmitt C; Roche Innovation Center, Basel, Switzerland., Jamois C; Roche Innovation Center, Basel, Switzerland., Siu LL; Princess Margaret Cancer Centre, Toronto, ON, Canada. lillian.siu@uhn.ca.
Source: Investigational new drugs [Invest New Drugs] 2021 Dec; Vol. 39 (6), pp. 1587-1597. Date of Electronic Publication: 2021 Jun 28.
Publication Type: Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8309330 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0646 (Electronic) Linking ISSN: 01676997 NLM ISO Abbreviation: Invest New Drugs Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1573-0646
DOI:10.1007/s10637-021-01141-2