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Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.

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Title: Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.
Authors: Cimino I; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom., Kim H; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA 02139., Tung YCL; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom., Pedersen K; Global Obesity and Liver Disease Research, Novo Nordisk A/S, DK-2760 Maaloev, Denmark., Rimmington D; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom., Tadross JA; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom.; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom., Kohnke SN; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom., Neves-Costa A; Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal., Barros A; Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal., Joaquim S; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA 02139., Bennett D; Biostatistics, Early Clinical Development, Pfizer Inc., Cambridge, MA 02139., Melvin A; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom., Lockhart SM; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom., Rostron AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.; Integrated Critical Care Unit, Sunderland Royal Hospital, South Tyneside and Sunderland NHS Foundation Trust, Sunderland SR4 7TP, United Kingdom., Scott J; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom., Liu H; Kymab Ltd., Cambridge CB22 3AT, United Kingdom., Burling K; Core Biochemical Assay Laboratories, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom., Barker P; Core Biochemical Assay Laboratories, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom., Clatworthy MR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, United Kingdom.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge CB2 0AW, United Kingdom.; Cellular Genetics, Wellcome Sanger Institute, Hinxton CB10 1RQ, United Kingdom., Lee EC; Kymab Ltd., Cambridge CB22 3AT, United Kingdom., Simpson AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom., Yeo GSH; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom., Moita LF; Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.; Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina, Universidade de Lisboa, 1649-004 Lisboa, Portugal., Bence KK; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA 02139., Jørgensen SB; Global Obesity and Liver Disease Research, Novo Nordisk A/S, DK-2760 Maaloev, Denmark., Coll AP; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom., Breen DM; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA 02139., O'Rahilly S; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom; so104@medschl.cam.ac.uk.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jul 06; Vol. 118 (27).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.
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  Data: <searchLink fieldCode="AU" term="%22Cimino+I%22">Cimino I</searchLink>; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Tung+YCL%22">Tung YCL</searchLink>; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Pedersen+K%22">Pedersen K</searchLink>; Global Obesity and Liver Disease Research, Novo Nordisk A/S, DK-2760 Maaloev, Denmark.<br /><searchLink fieldCode="AU" term="%22Rimmington+D%22">Rimmington D</searchLink>; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tadross+JA%22">Tadross JA</searchLink>; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom.; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kohnke+SN%22">Kohnke SN</searchLink>; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Neves-Costa+A%22">Neves-Costa A</searchLink>; Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.<br /><searchLink fieldCode="AU" term="%22Barros+A%22">Barros A</searchLink>; Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.<br /><searchLink fieldCode="AU" term="%22Joaquim+S%22">Joaquim S</searchLink>; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Bennett+D%22">Bennett D</searchLink>; Biostatistics, Early Clinical Development, Pfizer Inc., Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Melvin+A%22">Melvin A</searchLink>; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lockhart+SM%22">Lockhart SM</searchLink>; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rostron+AJ%22">Rostron AJ</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.; Integrated Critical Care Unit, Sunderland Royal Hospital, South Tyneside and Sunderland NHS Foundation Trust, Sunderland SR4 7TP, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Scott+J%22">Scott J</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Kymab Ltd., Cambridge CB22 3AT, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Burling+K%22">Burling K</searchLink>; Core Biochemical Assay Laboratories, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Barker+P%22">Barker P</searchLink>; Core Biochemical Assay Laboratories, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Clatworthy+MR%22">Clatworthy MR</searchLink>; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, United Kingdom.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge CB2 0AW, United Kingdom.; Cellular Genetics, Wellcome Sanger Institute, Hinxton CB10 1RQ, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lee+EC%22">Lee EC</searchLink>; Kymab Ltd., Cambridge CB22 3AT, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Simpson+AJ%22">Simpson AJ</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Yeo+GSH%22">Yeo GSH</searchLink>; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Moita+LF%22">Moita LF</searchLink>; Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.; Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina, Universidade de Lisboa, 1649-004 Lisboa, Portugal.<br /><searchLink fieldCode="AU" term="%22Bence+KK%22">Bence KK</searchLink>; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22Jørgensen+SB%22">Jørgensen SB</searchLink>; Global Obesity and Liver Disease Research, Novo Nordisk A/S, DK-2760 Maaloev, Denmark.<br /><searchLink fieldCode="AU" term="%22Coll+AP%22">Coll AP</searchLink>; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Breen+DM%22">Breen DM</searchLink>; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA 02139.<br /><searchLink fieldCode="AU" term="%22O'Rahilly+S%22">O'Rahilly S</searchLink>; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0SL, United Kingdom; so104@medschl.cam.ac.uk.
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