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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease.

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Title: Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease.
Authors: Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K., Fujisawa R; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., McClure AW; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K., Deegan TD; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Wu M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K., Ulferts R; Cell Biology of Infection Laboratory, the Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K., Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K., Drury LS; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K., Bertolin AP; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K., Zeng J; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K., Beale R; Cell Biology of Infection Laboratory, the Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K., Howell M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K., Labib K; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Source: The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2465-2479.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease.
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  Data: <searchLink fieldCode="AU" term="%22Canal+B%22">Canal B</searchLink>; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.<br /><searchLink fieldCode="AU" term="%22Fujisawa+R%22">Fujisawa R</searchLink>; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22McClure+AW%22">McClure AW</searchLink>; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.<br /><searchLink fieldCode="AU" term="%22Deegan+TD%22">Deegan TD</searchLink>; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Wu+M%22">Wu M</searchLink>; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.<br /><searchLink fieldCode="AU" term="%22Ulferts+R%22">Ulferts R</searchLink>; Cell Biology of Infection Laboratory, the Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.<br /><searchLink fieldCode="AU" term="%22Weissmann+F%22">Weissmann F</searchLink>; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.<br /><searchLink fieldCode="AU" term="%22Drury+LS%22">Drury LS</searchLink>; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.<br /><searchLink fieldCode="AU" term="%22Bertolin+AP%22">Bertolin AP</searchLink>; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.<br /><searchLink fieldCode="AU" term="%22Zeng+J%22">Zeng J</searchLink>; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.<br /><searchLink fieldCode="AU" term="%22Beale+R%22">Beale R</searchLink>; Cell Biology of Infection Laboratory, the Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.<br /><searchLink fieldCode="AU" term="%22Howell+M%22">Howell M</searchLink>; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.<br /><searchLink fieldCode="AU" term="%22Labib+K%22">Labib K</searchLink>; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Diffley+JFX%22">Diffley JFX</searchLink>; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Published+by+Portland+Press+on+behalf+of+the+Biochemical+Society%22">Published by Portland Press on behalf of the Biochemical Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2984726R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1470-8728 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202646021%22">02646021 </searchLink><i>NLM ISO Abbreviation: </i>Biochem J <i>Subsets: </i>MEDLINE
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