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The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.

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Title: The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
Authors: Murithi JM; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Deni I; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Okombo J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Bridgford JL; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Gnädig NF; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Edwards RL; Division of Infectious Diseases, Allergy and Immunology, Center for Vaccine Development, St. Louis University, St. Louis, MO 63104, USA., Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Mok S; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Burkhard AY; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Coburn-Flynn O; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Istvan ES; Department of Medicine, Division of Infectious Diseases, and Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Sakata-Kato T; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142, USA., Gomez-Lorenzo MG; Global Health Pharma Research Unit, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain., Cowell AN; School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA., Wicht KJ; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Drug Discovery and Development Center (H3D) and South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa., Le Manach C; Drug Discovery and Development Center (H3D) and South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa., Kalantarov GF; Division of Experimental Therapeutics, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Dey S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Duffey M; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Laleu B; Medicines for Malaria Venture, 1215 Geneva, Switzerland., Lukens AK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142, USA., Ottilie S; School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA., Vanaerschot M; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Trakht IN; Division of Experimental Therapeutics, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Gamo FJ; Global Health Pharma Research Unit, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain., Wirth DF; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142, USA., Goldberg DE; Department of Medicine, Division of Infectious Diseases, and Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Odom John AR; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Chibale K; Drug Discovery and Development Center (H3D) and South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa., Winzeler EA; School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: df2260@cumc.columbia.edu.
Source: Cell chemical biology [Cell Chem Biol] 2022 May 19; Vol. 29 (5), pp. 824-839.e6. Date of Electronic Publication: 2021 Jul 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
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  Data: The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
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Chan School of Public Health, Boston, MA 02115, USA; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Ottilie+S%22">Ottilie S</searchLink>; School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Vanaerschot+M%22">Vanaerschot M</searchLink>; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Trakht+IN%22">Trakht IN</searchLink>; Division of Experimental Therapeutics, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Gamo+FJ%22">Gamo FJ</searchLink>; Global Health Pharma Research Unit, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Wirth+DF%22">Wirth DF</searchLink>; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Goldberg+DE%22">Goldberg DE</searchLink>; Department of Medicine, Division of Infectious Diseases, and Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.<br /><searchLink fieldCode="AU" term="%22Odom+John+AR%22">Odom John AR</searchLink>; Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Chibale+K%22">Chibale K</searchLink>; Drug Discovery and Development Center (H3D) and South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa.<br /><searchLink fieldCode="AU" term="%22Winzeler+EA%22">Winzeler EA</searchLink>; School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Niles+JC%22">Niles JC</searchLink>; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Fidock+DA%22">Fidock DA</searchLink>; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: df2260@cumc.columbia.edu.
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  Data: <searchLink fieldCode="JN" term="%22101676030%22">Cell chemical biology</searchLink> [Cell Chem Biol] 2022 May 19; Vol. 29 (5), pp. 824-839.e6. <i>Date of Electronic Publication: </i>2021 Jul 06.
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