Effect of Esketamine Nasal Spray on Olfactory Function and Nasal Tolerability in Patients with Treatment-Resistant Depression: Results from Four Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Studies.

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Title: Effect of Esketamine Nasal Spray on Olfactory Function and Nasal Tolerability in Patients with Treatment-Resistant Depression: Results from Four Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Studies.
Authors: Doty RL; Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Popova V; Janssen Research & Development, Turnhoutseweg 30, 2340, Beerse, BE, Belgium. vpopova@its.jnj.com., Wylie C; Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Fedgchin M; Janssen Research & Development, LLC, Titusville, NJ, USA., Daly E; Janssen Scientific Affairs, LLC, Titusville, NJ, USA., Janik A; Janssen Research & Development, LLC, San Diego, CA, USA., Ochs-Ross R; Janssen Research & Development, LLC, Titusville, NJ, USA., Lane R; Janssen Research & Development, LLC, Titusville, NJ, USA., Lim P; Janssen Research & Development, LLC, Titusville, NJ, USA., Cooper K; Janssen Research & Development, LLC, Spring House, PA, USA., Melkote R; Janssen Research & Development, LLC, Titusville, NJ, USA., Jamieson C; Janssen Research & Development, LLC, Milpitas, CA, USA., Singh J; Janssen Research & Development, LLC, San Diego, CA, USA.; Neurocrine Biosciences, San Diego, CA, USA., Drevets WC; Janssen Research & Development, LLC, San Diego, CA, USA.
Source: CNS drugs [CNS Drugs] 2021 Jul; Vol. 35 (7), pp. 781-794. Date of Electronic Publication: 2021 Jul 07.
Publication Type: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9431220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1934 (Electronic) Linking ISSN: 11727047 NLM ISO Abbreviation: CNS Drugs Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1179-1934
DOI:10.1007/s40263-021-00826-9