Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis.

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Title: Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis.
Authors: Vitanza NA; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA. nicholas.vitanza@seattlechildrens.org.; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA. nicholas.vitanza@seattlechildrens.org., Johnson AJ; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA., Wilson AL; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA., Brown C; Seattle Children's Therapeutics, Seattle, WA, USA.; Therapeutic Cell Production Core, Seattle Children's Research Institute, Seattle, WA, USA., Yokoyama JK; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA., Künkele A; Department of Pediatric Oncology and Hematology, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA., Chang CA; Office of Animal Care, Seattle Children's Research Institute, Seattle, WA, USA., Rawlings-Rhea S; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA., Huang W; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA., Seidel K; Seattle Children's Therapeutics, Seattle, WA, USA., Albert CM; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA., Pinto N; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA., Gust J; Department of Neurology, University of Washington, Seattle, WA, USA.; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Finn LS; Department of Laboratories, Seattle Children's Hospital, Seattle, WA, USA.; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA., Ojemann JG; Division of Neurosurgery, Department of Neurological Surgery, Seattle Children's Hospital, Seattle, WA, USA., Wright J; Department of Radiology, Seattle Children's Hospital, Seattle, WA, USA., Orentas RJ; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA., Baldwin M; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA., Gardner RA; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA., Jensen MC; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA., Park JR; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA.
Source: Nature medicine [Nat Med] 2021 Sep; Vol. 27 (9), pp. 1544-1552. Date of Electronic Publication: 2021 Jul 12.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-170X
DOI:10.1038/s41591-021-01404-8