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Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis.

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Title: Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis.
Authors: Vitanza NA; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA. nicholas.vitanza@seattlechildrens.org.; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA. nicholas.vitanza@seattlechildrens.org., Johnson AJ; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA., Wilson AL; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA., Brown C; Seattle Children's Therapeutics, Seattle, WA, USA.; Therapeutic Cell Production Core, Seattle Children's Research Institute, Seattle, WA, USA., Yokoyama JK; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA., Künkele A; Department of Pediatric Oncology and Hematology, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA., Chang CA; Office of Animal Care, Seattle Children's Research Institute, Seattle, WA, USA., Rawlings-Rhea S; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA., Huang W; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA., Seidel K; Seattle Children's Therapeutics, Seattle, WA, USA., Albert CM; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA., Pinto N; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA., Gust J; Department of Neurology, University of Washington, Seattle, WA, USA.; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Finn LS; Department of Laboratories, Seattle Children's Hospital, Seattle, WA, USA.; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA., Ojemann JG; Division of Neurosurgery, Department of Neurological Surgery, Seattle Children's Hospital, Seattle, WA, USA., Wright J; Department of Radiology, Seattle Children's Hospital, Seattle, WA, USA., Orentas RJ; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA., Baldwin M; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA., Gardner RA; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA., Jensen MC; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA., Park JR; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA.
Source: Nature medicine [Nat Med] 2021 Sep; Vol. 27 (9), pp. 1544-1552. Date of Electronic Publication: 2021 Jul 12.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis.
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  Data: <searchLink fieldCode="AU" term="%22Vitanza+NA%22">Vitanza NA</searchLink>; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA. nicholas.vitanza@seattlechildrens.org.; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA. nicholas.vitanza@seattlechildrens.org.<br /><searchLink fieldCode="AU" term="%22Johnson+AJ%22">Johnson AJ</searchLink>; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+AL%22">Wilson AL</searchLink>; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Brown+C%22">Brown C</searchLink>; Seattle Children's Therapeutics, Seattle, WA, USA.; Therapeutic Cell Production Core, Seattle Children's Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Yokoyama+JK%22">Yokoyama JK</searchLink>; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Künkele+A%22">Künkele A</searchLink>; Department of Pediatric Oncology and Hematology, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Chang+CA%22">Chang CA</searchLink>; Office of Animal Care, Seattle Children's Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Rawlings-Rhea+S%22">Rawlings-Rhea S</searchLink>; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Seidel+K%22">Seidel K</searchLink>; Seattle Children's Therapeutics, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Albert+CM%22">Albert CM</searchLink>; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Pinto+N%22">Pinto N</searchLink>; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Gust+J%22">Gust J</searchLink>; Department of Neurology, University of Washington, Seattle, WA, USA.; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Finn+LS%22">Finn LS</searchLink>; Department of Laboratories, Seattle Children's Hospital, Seattle, WA, USA.; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ojemann+JG%22">Ojemann JG</searchLink>; Division of Neurosurgery, Department of Neurological Surgery, Seattle Children's Hospital, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Wright+J%22">Wright J</searchLink>; Department of Radiology, Seattle Children's Hospital, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Orentas+RJ%22">Orentas RJ</searchLink>; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Baldwin+M%22">Baldwin M</searchLink>; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Gardner+RA%22">Gardner RA</searchLink>; The Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA, USA.; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Jensen+MC%22">Jensen MC</searchLink>; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Park+JR%22">Park JR</searchLink>; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Washington, Seattle, WA, USA.; Seattle Children's Therapeutics, Seattle, WA, USA.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2021 Sep; Vol. 27 (9), pp. 1544-1552. <i>Date of Electronic Publication: </i>2021 Jul 12.
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