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Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo.

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Title: Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo.
Authors: Laber S; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK. slaber@broadinstitute.org sara.forcisi@helmholtz-muenchen.de melina@broadinstitute.org r.cox@har.mrc.ac.uk.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Forcisi S; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany. slaber@broadinstitute.org sara.forcisi@helmholtz-muenchen.de melina@broadinstitute.org r.cox@har.mrc.ac.uk.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Bentley L; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK., Petzold J; Institute of Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Moritz F; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany., Smirnov KS; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany., Al Sadat L; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Else Kröner-Fresenius-Centre for Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Williamson I; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK., Strobel S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute of Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Agnew T; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK., Sengupta S; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK., Nicol T; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK., Grallert H; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Center Munich, Germany., Heier M; KORA Study Center Augsburg, University Hospital of Augsburg, Augsburg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, Munich, Germany., Honecker J; Else Kröner-Fresenius-Centre for Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Mianne J; Mary Lyon Centre, MRC Harwell Institute, Oxfordshire, UK., Teboul L; Mary Lyon Centre, MRC Harwell Institute, Oxfordshire, UK., Dumbell R; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK., Long H; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK.; Nuffield Department of Medicine, University of Oxford, Henry Wellcome Building for Molecular Physiology, Old Road Campus, Headington, Oxford OX3 7BN, UK., Simon M; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK., Lindgren C; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK., Bickmore WA; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK., Hauner H; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Else Kröner-Fresenius-Centre for Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Schmitt-Kopplin P; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Analytical Food Chemistry, Technical University of Munich, Freising, Germany., Claussnitzer M; Broad Institute of MIT and Harvard, Cambridge, MA, USA. slaber@broadinstitute.org sara.forcisi@helmholtz-muenchen.de melina@broadinstitute.org r.cox@har.mrc.ac.uk.; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, Boston, MA, USA., Cox RD; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK. slaber@broadinstitute.org sara.forcisi@helmholtz-muenchen.de melina@broadinstitute.org r.cox@har.mrc.ac.uk.
Source: Science advances [Sci Adv] 2021 Jul 21; Vol. 7 (30). Date of Electronic Publication: 2021 Jul 21 (Print Publication: 2021).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo.
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  Data: <searchLink fieldCode="AU" term="%22Laber+S%22">Laber S</searchLink>; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK. slaber@broadinstitute.org sara.forcisi@helmholtz-muenchen.de melina@broadinstitute.org r.cox@har.mrc.ac.uk.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Forcisi+S%22">Forcisi S</searchLink>; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany. slaber@broadinstitute.org sara.forcisi@helmholtz-muenchen.de melina@broadinstitute.org r.cox@har.mrc.ac.uk.; German Center for Diabetes Research (DZD), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Bentley+L%22">Bentley L</searchLink>; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK.<br /><searchLink fieldCode="AU" term="%22Petzold+J%22">Petzold J</searchLink>; Institute of Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Moritz+F%22">Moritz F</searchLink>; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Smirnov+KS%22">Smirnov KS</searchLink>; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Al+Sadat+L%22">Al Sadat L</searchLink>; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Else Kröner-Fresenius-Centre for Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Williamson+I%22">Williamson I</searchLink>; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Strobel+S%22">Strobel S</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute of Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Agnew+T%22">Agnew T</searchLink>; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK.<br /><searchLink fieldCode="AU" term="%22Sengupta+S%22">Sengupta S</searchLink>; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK.<br /><searchLink fieldCode="AU" term="%22Nicol+T%22">Nicol T</searchLink>; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK.<br /><searchLink fieldCode="AU" term="%22Grallert+H%22">Grallert H</searchLink>; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Center Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Heier+M%22">Heier M</searchLink>; KORA Study Center Augsburg, University Hospital of Augsburg, Augsburg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Honecker+J%22">Honecker J</searchLink>; Else Kröner-Fresenius-Centre for Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mianne+J%22">Mianne J</searchLink>; Mary Lyon Centre, MRC Harwell Institute, Oxfordshire, UK.<br /><searchLink fieldCode="AU" term="%22Teboul+L%22">Teboul L</searchLink>; Mary Lyon Centre, MRC Harwell Institute, Oxfordshire, UK.<br /><searchLink fieldCode="AU" term="%22Dumbell+R%22">Dumbell R</searchLink>; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK.<br /><searchLink fieldCode="AU" term="%22Long+H%22">Long H</searchLink>; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK.; Nuffield Department of Medicine, University of Oxford, Henry Wellcome Building for Molecular Physiology, Old Road Campus, Headington, Oxford OX3 7BN, UK.<br /><searchLink fieldCode="AU" term="%22Simon+M%22">Simon M</searchLink>; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK.<br /><searchLink fieldCode="AU" term="%22Lindgren+C%22">Lindgren C</searchLink>; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK.<br /><searchLink fieldCode="AU" term="%22Bickmore+WA%22">Bickmore WA</searchLink>; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Hauner+H%22">Hauner H</searchLink>; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Else Kröner-Fresenius-Centre for Nutritional Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schmitt-Kopplin+P%22">Schmitt-Kopplin P</searchLink>; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Analytical Food Chemistry, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Claussnitzer+M%22">Claussnitzer M</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA. slaber@broadinstitute.org sara.forcisi@helmholtz-muenchen.de melina@broadinstitute.org r.cox@har.mrc.ac.uk.; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cox+RD%22">Cox RD</searchLink>; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire OX11 0RD, UK. slaber@broadinstitute.org sara.forcisi@helmholtz-muenchen.de melina@broadinstitute.org r.cox@har.mrc.ac.uk.
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