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A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.

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Title: A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.
Authors: Maehigashi T; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, United States of America., Ahn S; ST Pharm Co., Ltd., Seoul, South Korea., Kim UI; ST Pharm Co., Ltd., Seoul, South Korea., Lindenberger J; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America., Oo A; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, United States of America., Koneru PC; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America., Mahboubi B; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, United States of America., Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America., Kvaratskhelia M; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America., Kim K; ST Pharm Co., Ltd., Seoul, South Korea., Kim B; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, United States of America.; Center for Drug Discovery, Children's Healthcare of Atlanta, Atlanta, Georgia, United States of America.
Source: PLoS pathogens [PLoS Pathog] 2021 Jul 22; Vol. 17 (7), pp. e1009671. Date of Electronic Publication: 2021 Jul 22 (Print Publication: 2021).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.
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  Data: <searchLink fieldCode="AU" term="%22Maehigashi+T%22">Maehigashi T</searchLink>; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Ahn+S%22">Ahn S</searchLink>; ST Pharm Co., Ltd., Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+UI%22">Kim UI</searchLink>; ST Pharm Co., Ltd., Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Lindenberger+J%22">Lindenberger J</searchLink>; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.<br /><searchLink fieldCode="AU" term="%22Oo+A%22">Oo A</searchLink>; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Koneru+PC%22">Koneru PC</searchLink>; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.<br /><searchLink fieldCode="AU" term="%22Mahboubi+B%22">Mahboubi B</searchLink>; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Engelman+AN%22">Engelman AN</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Kvaratskhelia+M%22">Kvaratskhelia M</searchLink>; Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.<br /><searchLink fieldCode="AU" term="%22Kim+K%22">Kim K</searchLink>; ST Pharm Co., Ltd., Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+B%22">Kim B</searchLink>; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, United States of America.; Center for Drug Discovery, Children's Healthcare of Atlanta, Atlanta, Georgia, United States of America.
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  Data: <searchLink fieldCode="JN" term="%22101238921%22">PLoS pathogens</searchLink> [PLoS Pathog] 2021 Jul 22; Vol. 17 (7), pp. e1009671. <i>Date of Electronic Publication: </i>2021 Jul 22 (<i>Print Publication: </i>2021).
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              Text: 2021 Jul 22
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