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3-Methyl-imidazo[2,1-b]thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations.

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Title: 3-Methyl-imidazo[2,1-b]thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations.
Authors: Ewida MA; Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt, Cairo 11835, Egypt., Ewida HA; Department of Pharmacology and Biochemistry, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt, Cairo 11835, Egypt., Ahmed MS; Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Allam HA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt., ElBagary RI; Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt, Cairo 11835, Egypt., George RF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. Electronic address: riham.eskandar@pharma.cu.edu.eg., Georgey HH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo 11777, Egypt. Electronic address: Hanan.hana@pharma.cu.edu.eg., El-Subbagh HI; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.. Electronic address: subbagh@mans.edu.eg.
Source: Bioorganic chemistry [Bioorg Chem] 2021 Oct; Vol. 115, pp. 105205. Date of Electronic Publication: 2021 Jul 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Ewida+MA%22">Ewida MA</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt, Cairo 11835, Egypt.<br /><searchLink fieldCode="AU" term="%22Ewida+HA%22">Ewida HA</searchLink>; Department of Pharmacology and Biochemistry, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt, Cairo 11835, Egypt.<br /><searchLink fieldCode="AU" term="%22Ahmed+MS%22">Ahmed MS</searchLink>; Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Allam+HA%22">Allam HA</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.<br /><searchLink fieldCode="AU" term="%22ElBagary+RI%22">ElBagary RI</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt, Cairo 11835, Egypt.<br /><searchLink fieldCode="AU" term="%22George+RF%22">George RF</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. Electronic address: riham.eskandar@pharma.cu.edu.eg.<br /><searchLink fieldCode="AU" term="%22Georgey+HH%22">Georgey HH</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo 11777, Egypt. Electronic address: Hanan.hana@pharma.cu.edu.eg.<br /><searchLink fieldCode="AU" term="%22El-Subbagh+HI%22">El-Subbagh HI</searchLink>; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.. Electronic address: subbagh@mans.edu.eg.
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