An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity.

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Title: An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity.
Authors: Xu Y; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Carrascosa LC; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands., Yeung YA; BMD, Pfizer Inc., San Diego, California., Chu ML; BMD, Pfizer Inc., San Diego, California., Yang W; Computational Biology, Pfizer Inc., San Diego, California., Djuretic I; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Pappas DC; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Zeytounian J; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Ge Z; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands., de Ruiter V; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands., Starbeck-Miller GR; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Patterson J; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Rigas D; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Chen SH; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Kraynov E; BMD, Pfizer Inc., San Diego, California., Boor PP; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands., Noordam L; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands., Doukas M; Pathology, Erasmus Medical Center, Rotterdam, the Netherlands., Tsao D; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Ijzermans JN; Surgery, Erasmus Medical Center, Rotterdam, the Netherlands., Guo J; BMD, Pfizer Inc., San Diego, California., Grünhagen DJ; Surgery, Erasmus Medical Center, Rotterdam, the Netherlands., Erdmann J; Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Verheij J; Pathology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., van Royen ME; Pathology, Erasmus Medical Center, Rotterdam, the Netherlands.; Cancer Treatment Screening Facility (CTSF), Erasmus Medical Center, Rotterdam, the Netherlands., Doornebosch PG; Surgery, IJsselland Hospital, Capelle aan den IJssel, the Netherlands., Feldman R; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Park T; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Mahmoudi S; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Dorywalska M; BMD, Pfizer Inc., San Diego, California., Ni I; BMD, Pfizer Inc., San Diego, California., Chin SM; BMD, Pfizer Inc., San Diego, California., Mistry T; BMD, Pfizer Inc., San Diego, California., Mosyak L; BMD, Pfizer Inc., San Diego, California., Lin L; BMD, Pfizer Inc., San Diego, California., Ching KA; Computational Biology, Pfizer Inc., San Diego, California., Lindquist KC; BMD, Pfizer Inc., San Diego, California., Ji C; DSRD, Pfizer Inc., San Diego, California., Londono LM; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Kuang B; BMD, Pfizer Inc., San Diego, California., Rickert R; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Kwekkeboom J; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands., Sprengers D; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands. javier.chaparro-riggers@pfizer.com d.sprengers@erasmusmc.nl tzu-hsuan.huang@pfizer.com., Huang TH; Cancer Immunology Discovery, Pfizer Inc., San Diego, California. javier.chaparro-riggers@pfizer.com d.sprengers@erasmusmc.nl tzu-hsuan.huang@pfizer.com., Chaparro-Riggers J; BMD, Pfizer Inc., San Diego, California. javier.chaparro-riggers@pfizer.com d.sprengers@erasmusmc.nl tzu-hsuan.huang@pfizer.com.
Source: Cancer immunology research [Cancer Immunol Res] 2021 Oct; Vol. 9 (10), pp. 1141-1157. Date of Electronic Publication: 2021 Aug 10.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2326-6074
DOI:10.1158/2326-6066.CIR-21-0058