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An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity.

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Title: An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity.
Authors: Xu Y; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Carrascosa LC; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands., Yeung YA; BMD, Pfizer Inc., San Diego, California., Chu ML; BMD, Pfizer Inc., San Diego, California., Yang W; Computational Biology, Pfizer Inc., San Diego, California., Djuretic I; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Pappas DC; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Zeytounian J; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Ge Z; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands., de Ruiter V; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands., Starbeck-Miller GR; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Patterson J; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Rigas D; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Chen SH; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Kraynov E; BMD, Pfizer Inc., San Diego, California., Boor PP; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands., Noordam L; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands., Doukas M; Pathology, Erasmus Medical Center, Rotterdam, the Netherlands., Tsao D; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Ijzermans JN; Surgery, Erasmus Medical Center, Rotterdam, the Netherlands., Guo J; BMD, Pfizer Inc., San Diego, California., Grünhagen DJ; Surgery, Erasmus Medical Center, Rotterdam, the Netherlands., Erdmann J; Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Verheij J; Pathology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., van Royen ME; Pathology, Erasmus Medical Center, Rotterdam, the Netherlands.; Cancer Treatment Screening Facility (CTSF), Erasmus Medical Center, Rotterdam, the Netherlands., Doornebosch PG; Surgery, IJsselland Hospital, Capelle aan den IJssel, the Netherlands., Feldman R; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Park T; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Mahmoudi S; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Dorywalska M; BMD, Pfizer Inc., San Diego, California., Ni I; BMD, Pfizer Inc., San Diego, California., Chin SM; BMD, Pfizer Inc., San Diego, California., Mistry T; BMD, Pfizer Inc., San Diego, California., Mosyak L; BMD, Pfizer Inc., San Diego, California., Lin L; BMD, Pfizer Inc., San Diego, California., Ching KA; Computational Biology, Pfizer Inc., San Diego, California., Lindquist KC; BMD, Pfizer Inc., San Diego, California., Ji C; DSRD, Pfizer Inc., San Diego, California., Londono LM; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Kuang B; BMD, Pfizer Inc., San Diego, California., Rickert R; Cancer Immunology Discovery, Pfizer Inc., San Diego, California., Kwekkeboom J; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands., Sprengers D; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands. javier.chaparro-riggers@pfizer.com d.sprengers@erasmusmc.nl tzu-hsuan.huang@pfizer.com., Huang TH; Cancer Immunology Discovery, Pfizer Inc., San Diego, California. javier.chaparro-riggers@pfizer.com d.sprengers@erasmusmc.nl tzu-hsuan.huang@pfizer.com., Chaparro-Riggers J; BMD, Pfizer Inc., San Diego, California. javier.chaparro-riggers@pfizer.com d.sprengers@erasmusmc.nl tzu-hsuan.huang@pfizer.com.
Source: Cancer immunology research [Cancer Immunol Res] 2021 Oct; Vol. 9 (10), pp. 1141-1157. Date of Electronic Publication: 2021 Aug 10.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity.
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Cancer Immunology Discovery, Pfizer Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Dorywalska+M%22">Dorywalska M</searchLink>; BMD, Pfizer Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Ni+I%22">Ni I</searchLink>; BMD, Pfizer Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Chin+SM%22">Chin SM</searchLink>; BMD, Pfizer Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Mistry+T%22">Mistry T</searchLink>; BMD, Pfizer Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Mosyak+L%22">Mosyak L</searchLink>; BMD, Pfizer Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Lin+L%22">Lin L</searchLink>; BMD, Pfizer Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Ching+KA%22">Ching KA</searchLink>; Computational Biology, Pfizer Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Lindquist+KC%22">Lindquist KC</searchLink>; BMD, Pfizer Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Ji+C%22">Ji C</searchLink>; DSRD, Pfizer Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Londono+LM%22">Londono LM</searchLink>; Cancer Immunology Discovery, Pfizer Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Kuang+B%22">Kuang B</searchLink>; BMD, Pfizer Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Rickert+R%22">Rickert R</searchLink>; Cancer Immunology Discovery, Pfizer Inc., San Diego, California.<br /><searchLink fieldCode="AU" term="%22Kwekkeboom+J%22">Kwekkeboom J</searchLink>; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sprengers+D%22">Sprengers D</searchLink>; Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands. javier.chaparro-riggers@pfizer.com d.sprengers@erasmusmc.nl tzu-hsuan.huang@pfizer.com.<br /><searchLink fieldCode="AU" term="%22Huang+TH%22">Huang TH</searchLink>; Cancer Immunology Discovery, Pfizer Inc., San Diego, California. javier.chaparro-riggers@pfizer.com d.sprengers@erasmusmc.nl tzu-hsuan.huang@pfizer.com.<br /><searchLink fieldCode="AU" term="%22Chaparro-Riggers+J%22">Chaparro-Riggers J</searchLink>; BMD, Pfizer Inc., San Diego, California. javier.chaparro-riggers@pfizer.com d.sprengers@erasmusmc.nl tzu-hsuan.huang@pfizer.com.
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