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Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children.

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Title: Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children.
Authors: Beckmann ND; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. noam.beckmann@mssm.edu.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA. noam.beckmann@mssm.edu., Comella PH; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cheng E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lepow L; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Beckmann AG; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tyler SR; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mouskas K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Simons NW; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hoffman GE; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Francoeur NJ; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA., Del Valle DM; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kang G; Department of Medicine, Division of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Do A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA., Moya E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wilkins L; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Le Berichel J; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chang C; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Marvin R; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Calorossi S; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lansky A; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Walker L; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Yi N; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Yu A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chung J; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hartnett M; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Eaton M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hatem S; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jamal H; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Akyatan A; Department of of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tabachnikova A; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Liharska LE; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cotter L; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fennessy B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Vaid A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Barturen G; Department of Medical Genomics, Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government (GENYO), Granada, Spain., Shah H; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang YC; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sridhar SH; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Soto J; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA., Bose S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA., Madrid K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA., Ellis E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA., Merzier E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA., Vlachos K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA., Fishman N; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA., Tin M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA., Smith M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA., Xie H; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Patel M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nie K; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Argueta K; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Harris J; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Karekar N; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Batchelor C; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lacunza J; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Yishak M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tuballes K; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Scott I; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kumar A; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jaladanki S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Agashe C; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Thompson R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA., Clark E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Losic B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Peters L; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Roussos P; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zhu J; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang W; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kasarskis A; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Glicksberg BS; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nadkarni G; Mount Sinai COVID Informatics Center, New York, NY, USA.; Department of Medicine, Mount Sinai, New York, NY, USA.; Hasso Plattner Institute for Digital Health at Mount Sinai, New York, NY, USA.; Charles Bronfman Institute for Personalized Medicine, New York, NY, USA., Bogunovic D; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Elaiho C; Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gangadharan S; Departments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ofori-Amanfo G; Departments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Alesso-Carra K; Departments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Onel K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Departments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wilson KM; Departments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Argmann C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bunyavanich S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA.; Departments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Alarcón-Riquelme ME; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Marron TU; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rahman A; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kim-Schulze S; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gnjatic S; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Hematology and Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gelb BD; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Departments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mindich Child Health and Development Institute at Mount Sinai, New York, NY, USA., Merad M; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sebra R; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA.; Black Family Stem Cell Institute, New York, NY, USA.; Sema4, a Mount Sinai Venture, Stamford, CT, USA., Schadt EE; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eric.schadt@mssm.edu.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA. eric.schadt@mssm.edu.; Sema4, a Mount Sinai Venture, Stamford, CT, USA. eric.schadt@mssm.edu., Charney AW; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. alexander.charney@mssm.edu.; Icahn Institute of Data Science and Genomics Technology, New York, NY, USA. alexander.charney@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. alexander.charney@mssm.edu.; Mount Sinai COVID Informatics Center, New York, NY, USA. alexander.charney@mssm.edu.
Corporate Authors: Mount Sinai COVID-19 Biobank Team
Source: Nature communications [Nat Commun] 2021 Aug 11; Vol. 12 (1), pp. 4854. Date of Electronic Publication: 2021 Aug 11.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-021-24981-1