A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies.
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| Title: | A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies. |
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| Authors: | Altmann A; Centre for Medical Image Computing, University College London, London, UK., Ryten M; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Di Nunzio M; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Ravizza T; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Tolomeo D; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Reynolds RH; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Somani A; Division of Neuropathology, UCL Queen Square Institute of Neurology, London, UK., Bacigaluppi M; Department of Neurology, San Raffaele Scientific Institute and Vita Salute San Raffaele University, Milan, Italy., Iori V; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Micotti E; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Di Sapia R; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Cerovic M; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Palma E; Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy., Ruffolo G; Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy., Botía JA; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.; Departamento de Ingeniería de la Información y las Comunicaciones, Universidad de Murcia, Murcia, Spain., Absil J; Department of Radiology, Hôpital Erasme, Universite Libre de Bruxelles, Brussels, Belgium., Alhusaini S; Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Neurology Department, Yale University School of Medicine, New Haven, CT, USA., Alvim MKM; Department of Neurology, University of Campinas, Campinas, Brazil., Auvinen P; Epilepsy Center, Department of Neurology, Kuopio University, Kuopio, Finland.; Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland., Bargallo N; Magnetic Resonance Image Core Facility, IDIBAPS, Barcelona, Spain.; Centre de Diagnostic Per la Imatge (CDIC), Hospital Clinic, Barcelona, Spain., Bartolini E; Pediatric Neurology Unit, Children's Hospital A. Meyer-University of Florence, Florence, Italy.; Neurology Unit, USL Centro Toscana, Nuovo Ospedale Santo Stefano, Prato, Italy., Bender B; Department of Diagnostic and Interventional Neuroradiology, University of Tübingen, Tübingen, Germany., Bergo FPG; Department of Neurology, University of Campinas, Campinas, Brazil., Bernardes T; Department of Neurology, University of Campinas, Campinas, Brazil., Bernasconi A; Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada., Bernasconi N; Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada., Bernhardt BC; Multimodal Imaging and Connectome Analysis Lab, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada., Blackmon K; Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA., Braga B; Department of Neurology, University of Campinas, Campinas, Brazil., Caligiuri ME; Neuroscience Research Center, Department of Medical and Surgical Sciences, University 'Magna Graecia' of Catanzaro, Catanzaro, Italy., Calvo A; Magnetic Resonance Image Core Facility, IDIBAPS, Barcelona, Spain., Carlson C; Comprehensive Epilepsy Center, Department of Neurology, New York University School of Medicine, New York, New York, USA.; Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Carr SJA; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Cavalleri GL; Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.; FutureNeuro Research Centre, RCSI, Dublin, Ireland., Cendes F; Department of Neurology, University of Campinas, Campinas, Brazil., Chen J; Department of Computer Science and Engineering, The Ohio State University, Columbus, Ohio, USA., Chen S; Cognitive Science Department, Xiamen University, Xiamen, China.; Fujian Key Laboratory of the Brain-like Intelligent Systems, Xiamen, China., Cherubini A; Neuroscience Research Center, Department of Medical and Surgical Sciences, University 'Magna Graecia' of Catanzaro, Catanzaro, Italy., Concha L; Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico., David P; Department of Radiology, Hôpital Erasme, Universite Libre de Bruxelles, Brussels, Belgium., Delanty N; Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.; FutureNeuro Research Centre, RCSI, Dublin, Ireland.; Division of Neurology, Beaumont Hospital, Dublin 9, Ireland., Depondt C; Department of Neurology, Hôpital Erasme, Universite Libre de Bruxelles, Brussels, Belgium., Devinsky O; Department of Neurology, Langone School of Medicine, New York University, New York, NY, USA., Doherty CP; FutureNeuro Research Centre, RCSI, Dublin, Ireland.; School of Medicine, Trinity College Dublin, Dublin, Ireland., Domin M; Functional Imaging Unit, Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany., Focke NK; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Department of Clinical Neurophysiology, University Medicine Göttingen, Göttingen, Germany., Foley S; The Welsh Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK., Franca W; Department of Neurology, University of Campinas, Campinas, Brazil., Gambardella A; Neuroscience Research Center, Department of Medical and Surgical Sciences, University 'Magna Graecia' of Catanzaro, Catanzaro, Italy.; Institute of Neurology, University 'Magna Graecia', Catanzaro, Italy., Guerrini R; Pediatric Neurology Unit, Children's Hospital A. Meyer-University of Florence, Florence, Italy., Hamandi K; The Welsh Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK.; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK., Hibar DP; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California, USA., Isaev D; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California, USA., Jackson GD; The Florey Institute of Neuroscience and Mental Health, Austin Campus, Melbourne, Victoria, Australia.; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia., Jahanshad N; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California, USA., Kälviäinen R; Epilepsy Center, Department of Neurology, Kuopio University, Kuopio, Finland.; Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland., Keller SS; Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Kochunov P; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA., Kotikalapudi R; Department of Diagnostic and Interventional Neuroradiology, University of Tübingen, Tübingen, Germany.; Functional Imaging Unit, Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Kowalczyk MA; The Florey Institute of Neuroscience and Mental Health, Austin Campus, Melbourne, Victoria, Australia., Kuzniecky R; Department of Neurology, Zucker Hofstra School of Medicine, New York, New York, USA., Kwan P; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia., Labate A; Neuroscience Research Center, Department of Medical and Surgical Sciences, University 'Magna Graecia' of Catanzaro, Catanzaro, Italy.; Institute of Neurology, University 'Magna Graecia', Catanzaro, Italy., Langner S; Functional Imaging Unit, Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany., Lenge M; Pediatric Neurology Unit, Children's Hospital A. Meyer-University of Florence, Florence, Italy., Liu M; Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada., Martin P; Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Mascalchi M; 'Mario Serio' Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy., Meletti S; Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, NOCSE Hospital, Modena, Italy., Morita-Sherman ME; Department of Neurology, University of Campinas, Campinas, Brazil.; Cleveland Clinic Neurological Institute, Cleveland, USA., O'Brien TJ; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; The Department of Medicine (The Royal Melbourne Hospital), The University of Melbourne, Parkville, Victoria, Australia., Pariente JC; Magnetic Resonance Image Core Facility, IDIBAPS, Barcelona, Spain., Richardson MP; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Neurology, King's College Hospital, London, UK., Rodriguez-Cruces R; Multimodal Imaging and Connectome Analysis Lab, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.; Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico., Rummel C; Support Center for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Bern, Switzerland., Saavalainen T; Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland.; Medical Imaging Unit, Central Finland Central Hospital, Jyväskylä, Finland., Semmelroch MK; The Florey Institute of Neuroscience and Mental Health, Austin Campus, Melbourne, Victoria, Australia.; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia., Severino M; Neuroradiology Unit, Department of Head and Neck and Neurosciences, Istituto Giannina Gaslini, Genoa, Italy., Striano P; Pediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy., Thesen T; Comprehensive Epilepsy Center, Department of Neurology, New York University School of Medicine, New York, New York, USA., Thomas RH; Institute of Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, UK., Tondelli M; Cleveland Clinic Neurological Institute, Cleveland, USA., Tortora D; Neuroradiology Unit, Department of Head and Neck and Neurosciences, Istituto Giannina Gaslini, Genoa, Italy., Vaudano AE; Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, NOCSE Hospital, Modena, Italy., Vivash L; Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.; Melbourne Brain Centre, Department of Medicine, University of Melbourne, Parkville, Victoria, Australia., von Podewils F; Department of Neurology, University Medicine Greifswald, Greifswald, Germany., Wagner J; Department of Neurology, University of Ulm and Universitäts- and Rehabilitationskliniken Ulm, Ulm, Germany., Weber B; Institute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany., Wiest R; Support Center for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Bern, Switzerland., Yasuda CL; Department of Neurology, University of Campinas, Campinas, Brazil., Zhang G; Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, Baltimore, Maryland, USA., Zhang J; Cognitive Science Department, Xiamen University, Xiamen, China.; Fujian Key Laboratory of the Brain-like Intelligent Systems, Xiamen, China., Leu C; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK., Avbersek A; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Thom M; Division of Neuropathology, UCL Queen Square Institute of Neurology, London, UK.; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK., Whelan CD; Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California, USA., Thompson P; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California, USA., McDonald CR; Multimodal Imaging Laboratory, University of California San Diego, San Diego, California, USA.; Department of Psychiatry, University of California San Diego, San Diego, California, USA., Vezzani A; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Sisodiya SM; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Chalfont Centre for Epilepsy, Bucks, UK. |
| Corporate Authors: | ENIGMA-Epilepsy Working Group, EpiPGX Consortium |
| Source: | Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2022 Feb; Vol. 48 (1), pp. e12758. Date of Electronic Publication: 2021 Sep 05. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7609829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2990 (Electronic) Linking ISSN: 03051846 NLM ISO Abbreviation: Neuropathol Appl Neurobiol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1365-2990 |
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| DOI: | 10.1111/nan.12758 |
