Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood.
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| Title: | Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood. |
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| Authors: | Skead K; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Vector Institute for Artificial Intelligence, Toronto, ON, Canada., Ang Houle A; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Abelson S; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Agbessi M; Ontario Institute for Cancer Research, Toronto, ON, Canada., Bruat V; Ontario Institute for Cancer Research, Toronto, ON, Canada., Lin B; Ontario Institute for Cancer Research, Toronto, ON, Canada., Soave D; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Mathematics, Wilfrid Laurier University, Waterloo, ON, Canada., Shlush L; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Wright S; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada., Dick J; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, Toronto, ON, Canada., Morris Q; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. morrisq@mskcc.org.; Vector Institute for Artificial Intelligence, Toronto, ON, Canada. morrisq@mskcc.org.; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States. morrisq@mskcc.org., Awadalla P; Ontario Institute for Cancer Research, Toronto, ON, Canada. Philip.awadalla@oicr.on.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Philip.awadalla@oicr.on.ca.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. Philip.awadalla@oicr.on.ca. |
| Source: | Nature communications [Nat Commun] 2021 Aug 13; Vol. 12 (1), pp. 4921. Date of Electronic Publication: 2021 Aug 13. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-021-25172-8 |
