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Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood.

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Title: Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood.
Authors: Skead K; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Vector Institute for Artificial Intelligence, Toronto, ON, Canada., Ang Houle A; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Abelson S; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Agbessi M; Ontario Institute for Cancer Research, Toronto, ON, Canada., Bruat V; Ontario Institute for Cancer Research, Toronto, ON, Canada., Lin B; Ontario Institute for Cancer Research, Toronto, ON, Canada., Soave D; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Mathematics, Wilfrid Laurier University, Waterloo, ON, Canada., Shlush L; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Wright S; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada., Dick J; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, Toronto, ON, Canada., Morris Q; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. morrisq@mskcc.org.; Vector Institute for Artificial Intelligence, Toronto, ON, Canada. morrisq@mskcc.org.; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States. morrisq@mskcc.org., Awadalla P; Ontario Institute for Cancer Research, Toronto, ON, Canada. Philip.awadalla@oicr.on.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Philip.awadalla@oicr.on.ca.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. Philip.awadalla@oicr.on.ca.
Source: Nature communications [Nat Commun] 2021 Aug 13; Vol. 12 (1), pp. 4921. Date of Electronic Publication: 2021 Aug 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Skead+K%22">Skead K</searchLink>; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Vector Institute for Artificial Intelligence, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Ang+Houle+A%22">Ang Houle A</searchLink>; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Abelson+S%22">Abelson S</searchLink>; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Agbessi+M%22">Agbessi M</searchLink>; Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bruat+V%22">Bruat V</searchLink>; Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lin+B%22">Lin B</searchLink>; Ontario Institute for Cancer Research, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Soave+D%22">Soave D</searchLink>; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Mathematics, Wilfrid Laurier University, Waterloo, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Shlush+L%22">Shlush L</searchLink>; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Wright+S%22">Wright S</searchLink>; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Dick+J%22">Dick J</searchLink>; Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Morris+Q%22">Morris Q</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. morrisq@mskcc.org.; Vector Institute for Artificial Intelligence, Toronto, ON, Canada. morrisq@mskcc.org.; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States. morrisq@mskcc.org.<br /><searchLink fieldCode="AU" term="%22Awadalla+P%22">Awadalla P</searchLink>; Ontario Institute for Cancer Research, Toronto, ON, Canada. Philip.awadalla@oicr.on.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Philip.awadalla@oicr.on.ca.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. Philip.awadalla@oicr.on.ca.
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