SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release.

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Title: SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release.
Authors: Junqueira C; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.; Instituto René Rachou, Fundação Oswaldo Cruz, Brazil., Crespo Â; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA., Ranjbar S; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Medicine, Harvard Medical School, USA., Lewandrowski M; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA., Ingber J; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA., de Lacerda LB; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.; Instituto René Rachou, Fundação Oswaldo Cruz, Brazil., Parry B; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA., Ravid S; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA., Clark S; Department of Microbiology, Blavatnik Institute, Harvard Medical School, USA., Ho F; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA., Vora SM; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, USA., Leger V; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, USA., Beakes C; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA., Margolin J; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA., Russell N; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA., Kays K; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA., Gehrke L; Department of Microbiology, Blavatnik Institute, Harvard Medical School, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, USA., Adhikari UD; Ragon Institute, Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, USA., Henderson L; Department of Pediatrics, Harvard Medical School, USA.; Division of Immunology, Boston Children's Hospital, USA., Janssen E; Department of Pediatrics, Harvard Medical School, USA.; Division of Immunology, Boston Children's Hospital, USA., Kwon D; Ragon Institute, Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, USA., Sander C; cBio Center, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA., Abraham J; Department of Microbiology, Blavatnik Institute, Harvard Medical School, USA., Filbin M; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA., Goldberg MB; Department of Microbiology, Blavatnik Institute, Harvard Medical School, USA.; Center for Bacterial Pathogenesis, Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, USA., Wu H; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.; Division of Immunology, Boston Children's Hospital, USA., Mehta G; Institute for Liver and Digestive Health, University College London, UK.; Institute of Hepatology, Foundation for Liver Research, London, UK., Bell S; Department of Clinical Neurosciences, University of Cambridge, UK., Goldfeld AE; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Medicine, Harvard Medical School, USA., Lieberman J; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.
Source: Research square [Res Sq] 2021 Aug 11. Date of Electronic Publication: 2021 Aug 11.
Publication Type: Preprint; Journal Article
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2693-5015
DOI:10.21203/rs.3.rs-153628/v1