View in EDS

SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release.

Saved in:
Bibliographic Details
Title: SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release.
Authors: Junqueira C; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.; Instituto René Rachou, Fundação Oswaldo Cruz, Brazil., Crespo Â; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA., Ranjbar S; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Medicine, Harvard Medical School, USA., Lewandrowski M; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA., Ingber J; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA., de Lacerda LB; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.; Instituto René Rachou, Fundação Oswaldo Cruz, Brazil., Parry B; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA., Ravid S; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA., Clark S; Department of Microbiology, Blavatnik Institute, Harvard Medical School, USA., Ho F; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA., Vora SM; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, USA., Leger V; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, USA., Beakes C; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA., Margolin J; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA., Russell N; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA., Kays K; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA., Gehrke L; Department of Microbiology, Blavatnik Institute, Harvard Medical School, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, USA., Adhikari UD; Ragon Institute, Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, USA., Henderson L; Department of Pediatrics, Harvard Medical School, USA.; Division of Immunology, Boston Children's Hospital, USA., Janssen E; Department of Pediatrics, Harvard Medical School, USA.; Division of Immunology, Boston Children's Hospital, USA., Kwon D; Ragon Institute, Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, USA., Sander C; cBio Center, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA., Abraham J; Department of Microbiology, Blavatnik Institute, Harvard Medical School, USA., Filbin M; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA., Goldberg MB; Department of Microbiology, Blavatnik Institute, Harvard Medical School, USA.; Center for Bacterial Pathogenesis, Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, USA., Wu H; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.; Division of Immunology, Boston Children's Hospital, USA., Mehta G; Institute for Liver and Digestive Health, University College London, UK.; Institute of Hepatology, Foundation for Liver Research, London, UK., Bell S; Department of Clinical Neurosciences, University of Cambridge, UK., Goldfeld AE; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Medicine, Harvard Medical School, USA., Lieberman J; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.
Source: Research square [Res Sq] 2021 Aug 11. Date of Electronic Publication: 2021 Aug 11.
Publication Type: Preprint; Journal Article
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 34401873
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Junqueira+C%22">Junqueira C</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.; Instituto René Rachou, Fundação Oswaldo Cruz, Brazil.<br /><searchLink fieldCode="AU" term="%22Crespo+Â%22">Crespo Â</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.<br /><searchLink fieldCode="AU" term="%22Ranjbar+S%22">Ranjbar S</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Medicine, Harvard Medical School, USA.<br /><searchLink fieldCode="AU" term="%22Lewandrowski+M%22">Lewandrowski M</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.<br /><searchLink fieldCode="AU" term="%22Ingber+J%22">Ingber J</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.<br /><searchLink fieldCode="AU" term="%22de+Lacerda+LB%22">de Lacerda LB</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.; Instituto René Rachou, Fundação Oswaldo Cruz, Brazil.<br /><searchLink fieldCode="AU" term="%22Parry+B%22">Parry B</searchLink>; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA.<br /><searchLink fieldCode="AU" term="%22Ravid+S%22">Ravid S</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.<br /><searchLink fieldCode="AU" term="%22Clark+S%22">Clark S</searchLink>; Department of Microbiology, Blavatnik Institute, Harvard Medical School, USA.<br /><searchLink fieldCode="AU" term="%22Ho+F%22">Ho F</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.<br /><searchLink fieldCode="AU" term="%22Vora+SM%22">Vora SM</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, USA.<br /><searchLink fieldCode="AU" term="%22Leger+V%22">Leger V</searchLink>; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, USA.<br /><searchLink fieldCode="AU" term="%22Beakes+C%22">Beakes C</searchLink>; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA.<br /><searchLink fieldCode="AU" term="%22Margolin+J%22">Margolin J</searchLink>; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA.<br /><searchLink fieldCode="AU" term="%22Russell+N%22">Russell N</searchLink>; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA.<br /><searchLink fieldCode="AU" term="%22Kays+K%22">Kays K</searchLink>; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA.<br /><searchLink fieldCode="AU" term="%22Gehrke+L%22">Gehrke L</searchLink>; Department of Microbiology, Blavatnik Institute, Harvard Medical School, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, USA.<br /><searchLink fieldCode="AU" term="%22Adhikari+UD%22">Adhikari UD</searchLink>; Ragon Institute, Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, USA.<br /><searchLink fieldCode="AU" term="%22Henderson+L%22">Henderson L</searchLink>; Department of Pediatrics, Harvard Medical School, USA.; Division of Immunology, Boston Children's Hospital, USA.<br /><searchLink fieldCode="AU" term="%22Janssen+E%22">Janssen E</searchLink>; Department of Pediatrics, Harvard Medical School, USA.; Division of Immunology, Boston Children's Hospital, USA.<br /><searchLink fieldCode="AU" term="%22Kwon+D%22">Kwon D</searchLink>; Ragon Institute, Massachusetts General Hospital, Massachusetts Institute of Technology, Harvard Medical School, USA.<br /><searchLink fieldCode="AU" term="%22Sander+C%22">Sander C</searchLink>; cBio Center, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Abraham+J%22">Abraham J</searchLink>; Department of Microbiology, Blavatnik Institute, Harvard Medical School, USA.<br /><searchLink fieldCode="AU" term="%22Filbin+M%22">Filbin M</searchLink>; Emergency Medicine, Massachusetts General Hospital Institute for Patient Care, USA.<br /><searchLink fieldCode="AU" term="%22Goldberg+MB%22">Goldberg MB</searchLink>; Department of Microbiology, Blavatnik Institute, Harvard Medical School, USA.; Center for Bacterial Pathogenesis, Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, USA.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.; Division of Immunology, Boston Children's Hospital, USA.<br /><searchLink fieldCode="AU" term="%22Mehta+G%22">Mehta G</searchLink>; Institute for Liver and Digestive Health, University College London, UK.; Institute of Hepatology, Foundation for Liver Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Bell+S%22">Bell S</searchLink>; Department of Clinical Neurosciences, University of Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Goldfeld+AE%22">Goldfeld AE</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Medicine, Harvard Medical School, USA.<br /><searchLink fieldCode="AU" term="%22Lieberman+J%22">Lieberman J</searchLink>; Program in Cellular and Molecular Medicine, Boston Children's Hospital, USA.; Department of Pediatrics, Harvard Medical School, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101768035%22">Research square</searchLink> [Res Sq] 2021 Aug 11. <i>Date of Electronic Publication: </i>2021 Aug 11.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Preprint; Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101768035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2693-5015 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226935015%22">26935015 </searchLink><i>NLM ISO Abbreviation: </i>Res Sq <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=34401873
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.21203/rs.3.rs-153628/v1
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Junqueira C
      – PersonEntity:
          Name:
            NameFull: Crespo Â
      – PersonEntity:
          Name:
            NameFull: Ranjbar S
      – PersonEntity:
          Name:
            NameFull: Lewandrowski M
      – PersonEntity:
          Name:
            NameFull: Ingber J
      – PersonEntity:
          Name:
            NameFull: de Lacerda LB
      – PersonEntity:
          Name:
            NameFull: Parry B
      – PersonEntity:
          Name:
            NameFull: Ravid S
      – PersonEntity:
          Name:
            NameFull: Clark S
      – PersonEntity:
          Name:
            NameFull: Ho F
      – PersonEntity:
          Name:
            NameFull: Vora SM
      – PersonEntity:
          Name:
            NameFull: Leger V
      – PersonEntity:
          Name:
            NameFull: Beakes C
      – PersonEntity:
          Name:
            NameFull: Margolin J
      – PersonEntity:
          Name:
            NameFull: Russell N
      – PersonEntity:
          Name:
            NameFull: Kays K
      – PersonEntity:
          Name:
            NameFull: Gehrke L
      – PersonEntity:
          Name:
            NameFull: Adhikari UD
      – PersonEntity:
          Name:
            NameFull: Henderson L
      – PersonEntity:
          Name:
            NameFull: Janssen E
      – PersonEntity:
          Name:
            NameFull: Kwon D
      – PersonEntity:
          Name:
            NameFull: Sander C
      – PersonEntity:
          Name:
            NameFull: Abraham J
      – PersonEntity:
          Name:
            NameFull: Filbin M
      – PersonEntity:
          Name:
            NameFull: Goldberg MB
      – PersonEntity:
          Name:
            NameFull: Wu H
      – PersonEntity:
          Name:
            NameFull: Mehta G
      – PersonEntity:
          Name:
            NameFull: Bell S
      – PersonEntity:
          Name:
            NameFull: Goldfeld AE
      – PersonEntity:
          Name:
            NameFull: Lieberman J
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 11
              M: 08
              Text: 2021 Aug 11
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-electronic
              Value: 2693-5015
          Titles:
            – TitleFull: Research square
              Type: main
ResultId 1