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Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.

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Bibliographic Details
Title: Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.
Authors: Zhang CH; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Spasov KA; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Reilly RA; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Hollander K; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Stone EA; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Ippolito JA; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Liosi ME; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Deshmukh MG; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.; M.D.-Ph.D. Program, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Tirado-Rives J; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Zhang S; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536-0812, United States., Liang Z; Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Miller SJ; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Isaacs F; Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Lindenbach BD; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536-0812, United States., Anderson KS; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Jorgensen WL; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Jul 14; Vol. 12 (8), pp. 1325-1332. Date of Electronic Publication: 2021 Jul 14 (Print Publication: 2021).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1948-5875
DOI:10.1021/acsmedchemlett.1c00326