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A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.

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Title: A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.
Authors: Temps C; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Lietha D; Margarita Salas Center for Biological Research (CIB), Spanish National Research Council (CSIC), Madrid, Spain., Webb ER; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Li XF; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom., Dawson JC; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Muir M; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Macleod KG; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Valero T; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Munro AF; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Contreras-Montoya R; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Luque-Ortega JR; Margarita Salas Center for Biological Research (CIB), Spanish National Research Council (CSIC), Madrid, Spain., Fraser C; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Beetham H; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Schoenherr C; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Lopalco M; Edinburgh Innovations Ltd., Edinburgh, United Kingdom., Arends MJ; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Frame MC; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Qian BZ; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom., Brunton VG; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Carragher NO; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Unciti-Broceta A; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom. asier.ub@ed.ac.uk.
Source: Cancer research [Cancer Res] 2021 Nov 01; Vol. 81 (21), pp. 5438-5450. Date of Electronic Publication: 2021 Aug 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-21-0613