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A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.

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Title: A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.
Authors: Temps C; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Lietha D; Margarita Salas Center for Biological Research (CIB), Spanish National Research Council (CSIC), Madrid, Spain., Webb ER; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Li XF; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom., Dawson JC; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Muir M; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Macleod KG; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Valero T; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Munro AF; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Contreras-Montoya R; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Luque-Ortega JR; Margarita Salas Center for Biological Research (CIB), Spanish National Research Council (CSIC), Madrid, Spain., Fraser C; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Beetham H; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Schoenherr C; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Lopalco M; Edinburgh Innovations Ltd., Edinburgh, United Kingdom., Arends MJ; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Frame MC; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Qian BZ; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom., Brunton VG; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Carragher NO; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom., Unciti-Broceta A; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom. asier.ub@ed.ac.uk.
Source: Cancer research [Cancer Res] 2021 Nov 01; Vol. 81 (21), pp. 5438-5450. Date of Electronic Publication: 2021 Aug 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.
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  Data: <searchLink fieldCode="AU" term="%22Temps+C%22">Temps C</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lietha+D%22">Lietha D</searchLink>; Margarita Salas Center for Biological Research (CIB), Spanish National Research Council (CSIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Webb+ER%22">Webb ER</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Li+XF%22">Li XF</searchLink>; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dawson+JC%22">Dawson JC</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Muir+M%22">Muir M</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Macleod+KG%22">Macleod KG</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Valero+T%22">Valero T</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Munro+AF%22">Munro AF</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Contreras-Montoya+R%22">Contreras-Montoya R</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Luque-Ortega+JR%22">Luque-Ortega JR</searchLink>; Margarita Salas Center for Biological Research (CIB), Spanish National Research Council (CSIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fraser+C%22">Fraser C</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Beetham+H%22">Beetham H</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Schoenherr+C%22">Schoenherr C</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lopalco+M%22">Lopalco M</searchLink>; Edinburgh Innovations Ltd., Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Arends+MJ%22">Arends MJ</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Frame+MC%22">Frame MC</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Qian+BZ%22">Qian BZ</searchLink>; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Brunton+VG%22">Brunton VG</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Carragher+NO%22">Carragher NO</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Unciti-Broceta+A%22">Unciti-Broceta A</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, United Kingdom. asier.ub@ed.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%222984705R%22">Cancer research</searchLink> [Cancer Res] 2021 Nov 01; Vol. 81 (21), pp. 5438-5450. <i>Date of Electronic Publication: </i>2021 Aug 20.
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