Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma.
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| Title: | Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma. |
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| Authors: | Nguyen TTT; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA., Shang E; Department of Biological Sciences, Bronx Community College, City University of New York, Bronx, New York, NY, USA., Shu C; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA., Kim S; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA., Mela A; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA., Humala N; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Mahajan A; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Yang HW; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA., Akman HO; Department of Neurology, Columbia University Medical Center, New York, NY, USA., Quinzii CM; Department of Neurology, Columbia University Medical Center, New York, NY, USA., Zhang G; Proteomics and Metabolomics Core Facility, Weill Cornell Medicine, New York, NY, USA., Westhoff MA; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany., Karpel-Massler G; Department of Neurosurgery, Ulm University Medical Center, Ulm, Germany., Bruce JN; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Canoll P; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA., Siegelin MD; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA. ms4169@cumc.columbia.edu. |
| Source: | Nature communications [Nat Commun] 2021 Sep 01; Vol. 12 (1), pp. 5203. Date of Electronic Publication: 2021 Sep 01. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-021-25501-x |