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Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.

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Title: Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.
Authors: Harshfield EL; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. eh457@medschl.cam.ac.uk.; Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK. eh457@medschl.cam.ac.uk., Fauman EB; Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, Massachusetts, 02139, USA., Stacey D; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Paul DS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, CB2 0QQ, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, CB2 0QQ, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, CB10 1SA, UK.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Ziemek D; Inflammation and Immunology, Pfizer Worldwide Research, Development and Medical, 10785, Berlin, Germany., Ong RMY; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK., Danesh J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, CB2 0QQ, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, CB2 0QQ, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, CB10 1SA, UK.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, CB2 0QQ, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, CB2 0QQ, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, CB10 1SA, UK.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Rasheed A; Center for Non-Communicable Diseases, Karachi, 75300, Pakistan., Sattar T; Center for Non-Communicable Diseases, Karachi, 75300, Pakistan., Zameer-Ul-Asar; Center for Non-Communicable Diseases, Karachi, 75300, Pakistan., Saleem I; Center for Non-Communicable Diseases, Karachi, 75300, Pakistan., Hina Z; Center for Non-Communicable Diseases, Karachi, 75300, Pakistan., Ishtiaq U; Center for Non-Communicable Diseases, Karachi, 75300, Pakistan., Qamar N; National Institute of Cardiovascular Diseases, Karachi, 75510, Pakistan., Mallick NH; Punjab Institute of Cardiology, Lahore, 42000, Pakistan., Yaqub Z; National Institute of Cardiovascular Diseases, Karachi, 75510, Pakistan., Saghir T; National Institute of Cardiovascular Diseases, Karachi, 75510, Pakistan., Rizvi SNH; National Institute of Cardiovascular Diseases, Karachi, 75510, Pakistan., Memon A; National Institute of Cardiovascular Diseases, Karachi, 75510, Pakistan., Ishaq M; Karachi Institute of Heart Diseases, Karachi, 75950, Pakistan., Rasheed SZ; Karachi Institute of Heart Diseases, Karachi, 75950, Pakistan., Memon FU; Red Crescent Institute of Cardiology, Hyderabad, 71500, Pakistan., Jalal A; Faisalabad Institute of Cardiology, Faisalabad, 38000, Pakistan., Abbas S; Faisalabad Institute of Cardiology, Faisalabad, 38000, Pakistan., Frossard P; Center for Non-Communicable Diseases, Karachi, 75300, Pakistan., Saleheen D; Center for Non-Communicable Diseases, Karachi, 75300, Pakistan.; Department of Biostatistics & Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA., Wood AM; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, CB2 0QQ, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, CB2 0QQ, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, CB10 1SA, UK.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Griffin JL; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, CB2 1GA, UK. julian.griffin@imperial.ac.uk.; Section of Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, SW7 2AZ, UK. julian.griffin@imperial.ac.uk., Koulman A; Core Metabolomics and Lipidomics Laboratory, National Institute for Health Research, Cambridge Biomedical Research Centre, Cambridge, CB2 0QQ, UK. ak675@medschl.cam.ac.uk.
Source: BMC medicine [BMC Med] 2021 Sep 10; Vol. 19 (1), pp. 232. Date of Electronic Publication: 2021 Sep 10.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1741-7015
DOI:10.1186/s12916-021-02087-1