View in EDS

A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.

Saved in:
Bibliographic Details
Title: A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.
Authors: Cosden M; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Jinn S; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Yao L; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Gretzula CA; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Kandebo M; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Toolan D; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Hatcher NG; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Ma L; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Lemaire W; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Adam GC; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Burlein C; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Minnick C; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Flick R; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Watt ML; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Mulhearn J; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, United States., Fraley M; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, United States., Drolet RE; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Marcus JN; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Smith SM; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States. Electronic address: sean_smith2@merck.com.
Source: Neurobiology of disease [Neurobiol Dis] 2021 Nov; Vol. 159, pp. 105507. Date of Electronic Publication: 2021 Sep 09.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1095-953X
DOI:10.1016/j.nbd.2021.105507