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A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.

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Title: A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.
Authors: Cosden M; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Jinn S; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Yao L; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Gretzula CA; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Kandebo M; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Toolan D; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Hatcher NG; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Ma L; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Lemaire W; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Adam GC; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Burlein C; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Minnick C; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Flick R; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Watt ML; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Mulhearn J; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, United States., Fraley M; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, United States., Drolet RE; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Marcus JN; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Smith SM; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States. Electronic address: sean_smith2@merck.com.
Source: Neurobiology of disease [Neurobiol Dis] 2021 Nov; Vol. 159, pp. 105507. Date of Electronic Publication: 2021 Sep 09.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE
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  Data: A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.
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  Data: <searchLink fieldCode="AU" term="%22Cosden+M%22">Cosden M</searchLink>; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Jinn+S%22">Jinn S</searchLink>; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Yao+L%22">Yao L</searchLink>; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Gretzula+CA%22">Gretzula CA</searchLink>; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Kandebo+M%22">Kandebo M</searchLink>; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Toolan+D%22">Toolan D</searchLink>; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Hatcher+NG%22">Hatcher NG</searchLink>; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Ma+L%22">Ma L</searchLink>; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Lemaire+W%22">Lemaire W</searchLink>; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Adam+GC%22">Adam GC</searchLink>; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Burlein+C%22">Burlein C</searchLink>; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Minnick+C%22">Minnick C</searchLink>; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Flick+R%22">Flick R</searchLink>; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Watt+ML%22">Watt ML</searchLink>; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Mulhearn+J%22">Mulhearn J</searchLink>; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Fraley+M%22">Fraley M</searchLink>; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Drolet+RE%22">Drolet RE</searchLink>; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Marcus+JN%22">Marcus JN</searchLink>; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States.<br /><searchLink fieldCode="AU" term="%22Smith+SM%22">Smith SM</searchLink>; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States. Electronic address: sean_smith2@merck.com.
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  Data: <searchLink fieldCode="JN" term="%229500169%22">Neurobiology of disease</searchLink> [Neurobiol Dis] 2021 Nov; Vol. 159, pp. 105507. <i>Date of Electronic Publication: </i>2021 Sep 09.
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        Value: 10.1016/j.nbd.2021.105507
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              Text: 2021 Nov
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