A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.
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| Title: | A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy. |
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| Authors: | Cosden M; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Jinn S; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Yao L; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Gretzula CA; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Kandebo M; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Toolan D; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Hatcher NG; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Ma L; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Lemaire W; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Adam GC; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Burlein C; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Minnick C; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Flick R; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Watt ML; Quantitative Biosciences, Merck & Co., Inc., West Point, PA 19486, United States., Mulhearn J; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, United States., Fraley M; Discovery Chemistry, Merck & Co., Inc., West Point, PA 19486, United States., Drolet RE; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Marcus JN; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States., Smith SM; Neuroscience Discovery, Merck & Co., Inc., West Point, PA 19486, United States. Electronic address: sean_smith2@merck.com. |
| Source: | Neurobiology of disease [Neurobiol Dis] 2021 Nov; Vol. 159, pp. 105507. Date of Electronic Publication: 2021 Sep 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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