Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity.

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Title: Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity.
Authors: Anfray C; IRCCS Humanitas Research Hospital, Rozzano, Italy., Mainini F; IRCCS Humanitas Research Hospital, Rozzano, Italy., Digifico E; IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy., Maeda A; IRCCS Humanitas Research Hospital, Rozzano, Italy., Sironi M; IRCCS Humanitas Research Hospital, Rozzano, Italy., Erreni M; IRCCS Humanitas Research Hospital, Rozzano, Italy., Anselmo A; IRCCS Humanitas Research Hospital, Rozzano, Italy., Ummarino A; IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy., Gandoy S; Center for Research in Molecular Medicine and Chronic Diseases, Santiago de Compostela, Spain., Expósito F; Department of Pathology, Anatomy and Physiology, University of Navarra, Pamplona, Spain., Redrado M; Department of Pathology, Anatomy and Physiology, University of Navarra, Pamplona, Spain., Serrano D; Department of Pathology, Anatomy and Physiology, University of Navarra, Pamplona, Spain., Calvo A; Department of Pathology, Anatomy and Physiology, University of Navarra, Pamplona, Spain., Martens M; Department of Bioinformatics, Maastricht University, Maastricht, Netherlands., Bravo S; Health Research Institute of Santigao de Compostela, Santiago de Compostela, Spain., Mantovani A; IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy., Allavena P; IRCCS Humanitas Research Hospital, Rozzano, Italy.; Humanitas University, Pieve Emanuele, Italy., Andón FT; IRCCS Humanitas Research Hospital, Rozzano, Italy fernando.torres.andon@usc.es.; Center for Research in Molecular Medicine and Chronic Diseases, Santiago de Compostela, Spain.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2021 Sep; Vol. 9 (9).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Print Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2051-1426
DOI:10.1136/jitc-2021-002408