SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.
Saved in:
| Title: | SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition. |
|---|---|
| Authors: | Ma J; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Shi Q; State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, 200438, China., Cui G; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Sheng H; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Botuyan MV; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Zhou Y; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Yan Y; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., He Y; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Wang L; Divison of Computational Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Wang Y; Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, BC, Canada., Mer G; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. mer.georges@mayo.edu.; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. mer.georges@mayo.edu.; Department of Cancer Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. mer.georges@mayo.edu., Ye D; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. Dwyeli@163.com.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Dwyeli@163.com., Wang C; State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, 200438, China. chenjiwang@fudan.edu.cn., Huang H; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. huang.haojie@mayo.edu.; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. huang.haojie@mayo.edu.; Department of Urology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. huang.haojie@mayo.edu. |
| Source: | Nature communications [Nat Commun] 2021 Oct 01; Vol. 12 (1), pp. 5779. Date of Electronic Publication: 2021 Oct 01. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| ISSN: | 2041-1723 |
|---|---|
| DOI: | 10.1038/s41467-021-26049-6 |
