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SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.

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Title: SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.
Authors: Ma J; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Shi Q; State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, 200438, China., Cui G; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Sheng H; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Botuyan MV; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Zhou Y; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Yan Y; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., He Y; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Wang L; Divison of Computational Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA., Wang Y; Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, BC, Canada., Mer G; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. mer.georges@mayo.edu.; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. mer.georges@mayo.edu.; Department of Cancer Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. mer.georges@mayo.edu., Ye D; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. Dwyeli@163.com.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Dwyeli@163.com., Wang C; State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, 200438, China. chenjiwang@fudan.edu.cn., Huang H; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. huang.haojie@mayo.edu.; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. huang.haojie@mayo.edu.; Department of Urology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. huang.haojie@mayo.edu.
Source: Nature communications [Nat Commun] 2021 Oct 01; Vol. 12 (1), pp. 5779. Date of Electronic Publication: 2021 Oct 01.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Shi+Q%22">Shi Q</searchLink>; State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, 200438, China.<br /><searchLink fieldCode="AU" term="%22Cui+G%22">Cui G</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Sheng+H%22">Sheng H</searchLink>; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Botuyan+MV%22">Botuyan MV</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Yan+Y%22">Yan Y</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Divison of Computational Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Experimental Therapeutics, BC Cancer Research Centre, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Mer+G%22">Mer G</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. mer.georges@mayo.edu.; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. mer.georges@mayo.edu.; Department of Cancer Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. mer.georges@mayo.edu.<br /><searchLink fieldCode="AU" term="%22Ye+D%22">Ye D</searchLink>; Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. Dwyeli@163.com.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Dwyeli@163.com.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; State Key Laboratory of Genetic Engineering, MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, 200438, China. chenjiwang@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. huang.haojie@mayo.edu.; Mayo Clinic Cancer Center, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. huang.haojie@mayo.edu.; Department of Urology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA. huang.haojie@mayo.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2021 Oct 01; Vol. 12 (1), pp. 5779. <i>Date of Electronic Publication: </i>2021 Oct 01.
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