Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19: The HEP-COVID Randomized Clinical Trial.
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| Title: | Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19: The HEP-COVID Randomized Clinical Trial. |
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| Authors: | Spyropoulos AC; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia., Goldin M; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York., Giannis D; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Diab W; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York., Wang J; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York., Khanijo S; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York., Mignatti A; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Department of Cardiology, Lenox Hill Hospital, Northwell Health, New York, New York., Gianos E; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Department of Cardiology, Lenox Hill Hospital, Northwell Health, New York, New York., Cohen M; Department of Medicine, Newark Beth Israel Medical Center, Newark, New Jersey., Sharifova G; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York., Lund JM; WellSpan York Hospital, York, Pennsylvania., Tafur A; Department of Medicine, Cardiovascular Institute, NorthShore University HealthSystem, Evanston, Illinois.; Division of Cardiology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois., Lewis PA; BayCare Health System, Inc, Clearwater, Florida., Cohoon KP; Division of Cardiovascular Medicine, Department of Medicine, Froedtert & the Medical College of Wisconsin, Milwaukee., Rahman H; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Biostatistics Unit, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Sison CP; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Biostatistics Unit, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Lesser ML; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.; Biostatistics Unit, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Ochani K; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Agrawal N; Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York., Hsia J; Colorado Prevention Center (CPC) Clinical Research, Aurora.; Division of Cardiology, University of Colorado School of Medicine, University of Colorado, Aurora., Anderson VE; Colorado Prevention Center (CPC) Clinical Research, Aurora., Bonaca M; Colorado Prevention Center (CPC) Clinical Research, Aurora.; Division of Cardiology, University of Colorado School of Medicine, University of Colorado, Aurora., Halperin JL; Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai Medical Center, New York, New York., Weitz JI; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada. |
| Corporate Authors: | HEP-COVID Investigators |
| Source: | JAMA internal medicine [JAMA Intern Med] 2021 Dec 01; Vol. 181 (12), pp. 1612-1620. |
| Publication Type: | Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 101589534 Publication Model: Print Cited Medium: Internet ISSN: 2168-6114 (Electronic) Linking ISSN: 21686106 NLM ISO Abbreviation: JAMA Intern Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2168-6114 |
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| DOI: | 10.1001/jamainternmed.2021.6203 |
