Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies.

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Title: Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies.
Authors: Szydłowski M; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Garbicz F; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Poland., Jabłońska E; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Górniak P; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Komar D; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Pyrzyńska B; Department of Immunology, Medical University of Warsaw, Warsaw, Poland., Bojarczuk K; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.; Department of Hematology and Medical Oncology, University Medicine Göttingen, Göttingen, Germany., Prochorec-Sobieszek M; Department of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Szumera-Ciećkiewicz A; Department of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Rymkiewicz G; Flow Cytometry Laboratory, Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Cybulska M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Statkiewicz M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Gajewska M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Mikula M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Gołas A; Ryvu Therapeutics, Cracow, Poland., Domagała J; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Poland.; Department of Immunology, Medical University of Warsaw, Warsaw, Poland., Winiarska M; Department of Immunology, Medical University of Warsaw, Warsaw, Poland., Graczyk-Jarzynka A; Department of Immunology, Medical University of Warsaw, Warsaw, Poland., Białopiotrowicz E; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Polak A; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Barankiewicz J; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Puła B; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Pawlak M; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Nowis D; Laboratory of Experimental Medicine, Medical University of Warsaw, Warsaw, Poland., Golab J; Department of Immunology, Medical University of Warsaw, Warsaw, Poland., Tomirotti AM; Department of Experimental and Translational Oncology, Menarini Ricerche, Pomezia, Italy., Brzózka K; Ryvu Therapeutics, Cracow, Poland., Pacheco-Blanco M; BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic., Kupcova K; BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic., Green MR; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Havranek O; BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic.; Department of Hematology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic., Chapuy B; Department of Hematology and Medical Oncology, University Medicine Göttingen, Göttingen, Germany., Juszczyński P; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland. pjuszczynski@ihit.waw.pl.
Source: Cancer research [Cancer Res] 2021 Dec 01; Vol. 81 (23), pp. 6029-6043. Date of Electronic Publication: 2021 Oct 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-21-1023