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Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies.

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Title: Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies.
Authors: Szydłowski M; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Garbicz F; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Poland., Jabłońska E; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Górniak P; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Komar D; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Pyrzyńska B; Department of Immunology, Medical University of Warsaw, Warsaw, Poland., Bojarczuk K; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.; Department of Hematology and Medical Oncology, University Medicine Göttingen, Göttingen, Germany., Prochorec-Sobieszek M; Department of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Szumera-Ciećkiewicz A; Department of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Rymkiewicz G; Flow Cytometry Laboratory, Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Cybulska M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Statkiewicz M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Gajewska M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Mikula M; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Gołas A; Ryvu Therapeutics, Cracow, Poland., Domagała J; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Poland.; Department of Immunology, Medical University of Warsaw, Warsaw, Poland., Winiarska M; Department of Immunology, Medical University of Warsaw, Warsaw, Poland., Graczyk-Jarzynka A; Department of Immunology, Medical University of Warsaw, Warsaw, Poland., Białopiotrowicz E; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Polak A; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Barankiewicz J; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Puła B; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Pawlak M; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Nowis D; Laboratory of Experimental Medicine, Medical University of Warsaw, Warsaw, Poland., Golab J; Department of Immunology, Medical University of Warsaw, Warsaw, Poland., Tomirotti AM; Department of Experimental and Translational Oncology, Menarini Ricerche, Pomezia, Italy., Brzózka K; Ryvu Therapeutics, Cracow, Poland., Pacheco-Blanco M; BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic., Kupcova K; BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic., Green MR; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Havranek O; BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic.; Department of Hematology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic., Chapuy B; Department of Hematology and Medical Oncology, University Medicine Göttingen, Göttingen, Germany., Juszczyński P; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland. pjuszczynski@ihit.waw.pl.
Source: Cancer research [Cancer Res] 2021 Dec 01; Vol. 81 (23), pp. 6029-6043. Date of Electronic Publication: 2021 Oct 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies.
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  Data: <searchLink fieldCode="AU" term="%22Szydłowski+M%22">Szydłowski M</searchLink>; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Garbicz+F%22">Garbicz F</searchLink>; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Jabłońska+E%22">Jabłońska E</searchLink>; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Górniak+P%22">Górniak P</searchLink>; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Komar+D%22">Komar D</searchLink>; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Pyrzyńska+B%22">Pyrzyńska B</searchLink>; Department of Immunology, Medical University of Warsaw, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Bojarczuk+K%22">Bojarczuk K</searchLink>; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.; Department of Hematology and Medical Oncology, University Medicine Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Prochorec-Sobieszek+M%22">Prochorec-Sobieszek M</searchLink>; Department of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Szumera-Ciećkiewicz+A%22">Szumera-Ciećkiewicz A</searchLink>; Department of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Rymkiewicz+G%22">Rymkiewicz G</searchLink>; Flow Cytometry Laboratory, Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Cybulska+M%22">Cybulska M</searchLink>; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Statkiewicz+M%22">Statkiewicz M</searchLink>; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Gajewska+M%22">Gajewska M</searchLink>; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Mikula+M%22">Mikula M</searchLink>; Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Gołas+A%22">Gołas A</searchLink>; Ryvu Therapeutics, Cracow, Poland.<br /><searchLink fieldCode="AU" term="%22Domagała+J%22">Domagała J</searchLink>; Postgraduate School of Molecular Medicine, Medical University of Warsaw, Poland.; Department of Immunology, Medical University of Warsaw, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Winiarska+M%22">Winiarska M</searchLink>; Department of Immunology, Medical University of Warsaw, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Graczyk-Jarzynka+A%22">Graczyk-Jarzynka A</searchLink>; Department of Immunology, Medical University of Warsaw, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Białopiotrowicz+E%22">Białopiotrowicz E</searchLink>; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Polak+A%22">Polak A</searchLink>; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Barankiewicz+J%22">Barankiewicz J</searchLink>; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Puła+B%22">Puła B</searchLink>; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Pawlak+M%22">Pawlak M</searchLink>; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Nowis+D%22">Nowis D</searchLink>; Laboratory of Experimental Medicine, Medical University of Warsaw, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Golab+J%22">Golab J</searchLink>; Department of Immunology, Medical University of Warsaw, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Tomirotti+AM%22">Tomirotti AM</searchLink>; Department of Experimental and Translational Oncology, Menarini Ricerche, Pomezia, Italy.<br /><searchLink fieldCode="AU" term="%22Brzózka+K%22">Brzózka K</searchLink>; Ryvu Therapeutics, Cracow, Poland.<br /><searchLink fieldCode="AU" term="%22Pacheco-Blanco+M%22">Pacheco-Blanco M</searchLink>; BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kupcova+K%22">Kupcova K</searchLink>; BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Green+MR%22">Green MR</searchLink>; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Havranek+O%22">Havranek O</searchLink>; BIOCEV, First Faculty of Medicine, Charles University, Prague, Czech Republic.; Department of Hematology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Chapuy+B%22">Chapuy B</searchLink>; Department of Hematology and Medical Oncology, University Medicine Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Juszczyński+P%22">Juszczyński P</searchLink>; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland. pjuszczynski@ihit.waw.pl.
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  Data: <searchLink fieldCode="JN" term="%222984705R%22">Cancer research</searchLink> [Cancer Res] 2021 Dec 01; Vol. 81 (23), pp. 6029-6043. <i>Date of Electronic Publication: </i>2021 Oct 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2984705R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7445 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200085472%22">00085472 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Res <i>Subsets: </i>MEDLINE
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