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Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.

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Title: Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.
Authors: Jarvis LB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Rainbow DB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Coppard V; Department of Medicine, University of Cambridge, Cambridge, UK., Howlett SK; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Georgieva Z; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Davies JL; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Mullay HK; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Hester J; Department of Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Ashmore T; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK., Van Den Bosch A; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Grist JT; Department of Radiology, University of Cambridge, Cambridge, UK., Coles AJ; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Mousa HS; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Pluchino S; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Mahbubani KT; Department of Surgery, University of Cambridge, Cambridge, UK., Griffin JL; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.; Imperial College London Dementia Research Institute & Section of Biomolecular Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK., Issa F; Department of Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Peruzzotti-Jametti L; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Wicker LS; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Jones JL; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. jls53@medschl.cam.ac.uk.
Source: Communications biology [Commun Biol] 2021 Oct 14; Vol. 4 (1), pp. 1186. Date of Electronic Publication: 2021 Oct 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.
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  Data: <searchLink fieldCode="AU" term="%22Jarvis+LB%22">Jarvis LB</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rainbow+DB%22">Rainbow DB</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Coppard+V%22">Coppard V</searchLink>; Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Howlett+SK%22">Howlett SK</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Georgieva+Z%22">Georgieva Z</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Davies+JL%22">Davies JL</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mullay+HK%22">Mullay HK</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Hester+J%22">Hester J</searchLink>; Department of Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ashmore+T%22">Ashmore T</searchLink>; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Van+Den+Bosch+A%22">Van Den Bosch A</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Grist+JT%22">Grist JT</searchLink>; Department of Radiology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Coles+AJ%22">Coles AJ</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mousa+HS%22">Mousa HS</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Pluchino+S%22">Pluchino S</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mahbubani+KT%22">Mahbubani KT</searchLink>; Department of Surgery, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Griffin+JL%22">Griffin JL</searchLink>; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.; Imperial College London Dementia Research Institute & Section of Biomolecular Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Saeb-Parsy+K%22">Saeb-Parsy K</searchLink>; Department of Surgery, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Issa+F%22">Issa F</searchLink>; Department of Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Peruzzotti-Jametti+L%22">Peruzzotti-Jametti L</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wicker+LS%22">Wicker LS</searchLink>; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Jones+JL%22">Jones JL</searchLink>; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. jls53@medschl.cam.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101719179%22">Communications biology</searchLink> [Commun Biol] 2021 Oct 14; Vol. 4 (1), pp. 1186. <i>Date of Electronic Publication: </i>2021 Oct 14.
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