Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies.

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Title: Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies.
Authors: Labrie M; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA. labriem@ohsu.edu.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA. labriem@ohsu.edu., Li A; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Creason A; Computational Biology Program, Oregon Health and Science University, Portland, OR, USA., Betts C; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Keck J; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA., Johnson B; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Sivagnanam S; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Computational Biology Program, Oregon Health and Science University, Portland, OR, USA., Boniface C; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA., Ma H; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Blucher A; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Chang YH; Computational Biology Program, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Chin K; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Vuky J; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Guimaraes AR; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Diagnostic Radiology, Oregon Health and Science University, Portland, OR, USA., Downey M; Department of Diagnostic Radiology, Oregon Health and Science University, Portland, OR, USA., Lim JY; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Gao L; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Siex K; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Parmar S; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Kolodzie A; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA., Spellman PT; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.; Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR, USA., Goecks J; Computational Biology Program, Oregon Health and Science University, Portland, OR, USA., Coussens LM; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA., Corless CL; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Pathology, Oregon Health and Science University, Portland, OR, USA., Bergan R; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA., Gray JW; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Center for Spatial Systems Biomedicine (OCSSB), Oregon Health and Science University, Portland, OR, USA.; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA., Mills GB; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR, USA.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mitri ZI; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA. mitri@ohsu.edu.
Source: NPJ precision oncology [NPJ Precis Oncol] 2021 Oct 19; Vol. 5 (1), pp. 92. Date of Electronic Publication: 2021 Oct 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2397-768X
DOI:10.1038/s41698-021-00232-w